… understanding of the genetic architecture of the LPA trait in Africans, we have performed a
family study in an autochthonous Black African population from rural Western Central Africa. …

… alleles were strongly determined by genetics, although with a varying ethnic … for Lp(a) level
in Africans versus Caucasians. Thus, the LPA locus explained almost all of the total genetic …

… , function, and genetics of Lp(a) with emphasis on the molecular and population genetics
of the Lp(a)/LPA trait, as well as aspects of genetic epidemiology. It highlights the role of …

… law regulating genetic research in Austria. … autochthonous African populations, including
the Egyptians, is in accordance with the mutation having occurred after the initial out-of-Africa …

… (in our case this was the number of KIV repeats determining apo(a) isoform size) have an
influence on Lp(a) concentrations (Fig. 3, panel b). Figure 4 is a simplified illustration how this …

… flanking nine genes, including LPA. We show that variation in at least six genes in addition to
LPA are significantly associated with Lp(… in the LPA gene. One novel SNP in intron 37 of the …

… into the genetic architecture of the apolipoprotein(a)/ lipoprotein(… The Gabonese described
in this study are noteworthy for the … LPA and plasma lipoprotein(a) levels in an autochthonous …

… a gap in our understanding of LPA respectively the apo(a)/Lp(a) trait, … It was found on two
African alleles (Gabonese and Khoi San), … to capture far more genetic variation than is currently …

… in the genetics of the LPA gene, risk categories of elevated … Black, 1,047 White, and 603
Hispanic individuals), the distribution of the major apo(a) isoform reflects the global population …

… We observe that genetic determinants between Europeans and Africans have several …
Using a comprehensive genetic instrument that separately imputes apo(a) isoform, we show …