Ginsenoside Rk3 alleviated DSS-induced ulcerative colitis by protecting colon barrier and inhibiting NLRP3 inflammasome pathway

M Tian, P Ma, Y Zhang, Y Mi, D Fan - International Immunopharmacology, 2020 - Elsevier
… of Rk3 on ulcerative colitis has rarely been reported. This study evaluated the effect of Rk3
on DSS-induced ulcerative colitisRk3 administration significantly attenuated the weight loss, …

[HTML][HTML] Natural products modulate NLRP3 in ulcerative colitis

JC Xue, S Yuan, XT Hou, H Meng, BH Liu… - Frontiers in …, 2023 - frontiersin.org
… effectively alleviate the symptoms of colitis in the DSS-induced UC … protective effect of
ginsenoside Rk3 on DSS-induced colitis … , repair intestinal barrier damage, and alleviate intestinal

Pharmacological effects of ginseng and ginsenosides on intestinal inflammation and the immune system

L Zhao, T Zhang, K Zhang - Frontiers in Immunology, 2024 - frontiersin.org
… can further reinforce intestinal barrier homeostasis through … and suppressing expression
levels of NLRP3 inflammasome. … Nakai could alleviate DSS-induced colitis through suppressing

Ginsenoside Rk3 alleviates gut microbiota dysbiosis and colonic inflammation in antibiotic-treated mice

X Bai, R Fu, Z Duan, P Wang, C Zhu, D Fan - Food Research International, 2021 - Elsevier
… activating the AMPK/Akt signaling pathway in HFD/STZ induced … Rk3 attenuated DSS-induced
ulcerative colitis by protecting the colonic barrier and inhibiting the NLRP3 inflammasome

[HTML][HTML] Therapeutic interventions target the NLRP3 inflammasome in ulcerative colitis: Comprehensive study

FEM Ali, IM Ibrahim, OM Ghogar… - World Journal of …, 2023 - ncbi.nlm.nih.gov
Ginsenoside Rk3 (Rk3) is a tetracyclic triterpenoid reportedly … protective effect on DSS-induced
colitis, suppressing the … formation of NLRP3 and protecting the intestinal barrier integrity. …

A review of ginsenosides from Panax ginseng in the treatment of inflammatory bowel disease

Z Niu, Y Liu, R Shen, X Jiang, Y Wang, Z He, J Li, Y Hu… - Phytomedicine, 2024 - Elsevier
… the intestinal barrier, regulating gut microbiota, and inhibiting … in intestinal immune disturbances
in DSS-induced colitis in … that selectively inhibit NLRP3 inflammasome activation may …

[HTML][HTML] Quyu Shengxin Decoction alleviates DSS-induced ulcerative colitis in mice by suppressing RIP1/RIP3/NLRP3 signalling

C Wu, H Yang, C Han, Q Wang, H Zhang… - Evidence-Based …, 2021 - hindawi.com
… polysaccharide reduces NLRP3 inflammasome activation … which form the first intestinal barrier,
defend intestinal health [30]… rates DSS-induced colitis by maintaining the epithelial barrier

Ginsenoside Rg1 Alleviates Ulcerative Colitis in Obese Mice by Regulating the Gut Microbiota–Lipid Metabolism–Th1/Th2/Th17 Cells Axis

Y Zhong, Q Xiao, J Huang, S Yu, L Chen… - Journal of Agricultural …, 2023 - ACS Publications
… and UC is impaired intestinal barrier function, which facilitates an … (B) DSS-induced colitis
model and ginsenoside Rg1 … of ginseng, such as panaxadiol and Rk3, have been found to …

Sinapic Acid Attenuates Chronic DSS-Induced Intestinal Fibrosis in C57BL/6J Mice by Modulating NLRP3 Inflammasome Activation and the Autophagy Pathway

WY Li, JY Liu, ZX Wang, KY Wang, CX Huang, W He… - ACS …, 2023 - ACS Publications
Ulcerative colitis (UC) is a subtype of inflammatory bowel … has a protective effect on colitis
mice by inhibiting inflammation … intestinal barrier integrity, inhibit the activation of the NLRP3

Zingiber officinale and Panax ginseng ameliorate ulcerative colitis in mice via modulating gut microbiota and its metabolites

Y Wan, L Yang, H Li, H Ren, K Zhu, Z Dong… - … of Chromatography B, 2022 - Elsevier
… gingerols, shogaols and ginsenosides, most of which have … mucosal barrier cells, was
involved in intestinal inflammation… protective effect against DSS-induced UC through alleviating