Glucosamine hydrochloride exerts a protective effect against unilateral ureteral obstruction-induced renal fibrosis by attenuating TGF-β signaling

J Park, SY Lee, A Ooshima, KM Yang, JM Kang… - Journal of Molecular …, 2013 - Springer
… obstruction (UUO)-induced renal fibrosis in vivo and TGF-β1-induced … GS-HCl decreased
the elevated TGF-β signaling in renal fibrosis. Further, we presented a mechanism that GS-HCl

[HTML][HTML] Glucosamine inhibits extracellular matrix accumulation in experimental diabetic nephropathy

L Teuma, R Eshwaran, U Tawokam Fongang… - Frontiers in …, 2022 - frontiersin.org
glucosamine in a model of non-diabetic renal fibrosis. A down-regulation of the TGF-β signaling
… Dapagliflozin attenuates renal tubulointerstitial fibrosis associated with type 1 diabetes …

Glucosamine and caveat emptor

FC Luft - Journal of Molecular Medicine, 2013 - Springer
… a Structure of glucosamine hydrochloride b Greatly … embryonic kidney-293 cell line exhibited
reduced TGF-β signaling … Should we commence with trials of glucosamine for renal fibrosis

Role of connective tissue growth factor in fibronectin expression and tubulointerstitial fibrosis

H Yokoi, M Mukoyama, A Sugawara… - … Physiology-Renal …, 2002 - journals.physiology.org
… the effect of blockade of endogenous CTGF on TGF-β-… into cultured renal fibroblasts
significantly attenuated TGF-β-… Besides stimulating fibrogenesis, CTGF exerts various biological …

Molecular mechanisms and biomedical applications of glucosamine as a potential multifunctional therapeutic agent

R Dalirfardouei, G Karimi, K Jamialahmadi - Life sciences, 2016 - Elsevier
… and cell survival and have protective effects at the cellular, … GlcNAc-modified proteins but
also through attenuation of NF-κB … glucosamine hydrochloride is an obstacle to TGF-β signaling

[HTML][HTML] Abelmoschus esculentus subfractions improved nephropathy with regulating dipeptidyl peptidase-4 and type 1 glucagon-like peptide receptor in type 2 …

CH Peng, HC Lin, CL Lin, CJ Wang… - Journal of food and drug …, 2019 - Elsevier
… F2 was most effective in attenuating hyperglycemia and insulin … F2 and FR exerted significant
effects to decrease DPP-4 but … by inhibiting N-linked glycosylation of the TGF-β receptor, …

The anti-fibrotic and anti-inflammatory effects of 2, 4-diamino-5-(1-hydroxynaphthalen-2-yl)-5H-chromeno [2, 3-b] pyriine-3-carbonitrile in corneal fibroblasts

YJ Chen, SM Huang, MC Tai, JT Chen, AR Lee… - Pharmacological …, 2020 - Springer
… with N1 significantly attenuated phosphorylation of both STAT3 … N1 exerts anti-fibrotic and
anti-inflammatory effects through … roles in relaying extracellular TGF-β signals, and that Smad3 …

Glucosamine impedes transforming growth factor β1-mediated corneal fibroblast differentiation by targeting Krüppel-like factor 4

YJ Chen, SM Huang, MC Tai, JT Chen… - Journal of Biomedical …, 2019 - Springer
… whether GlcN affects signaling via TGF-β receptors (TGF-βRs… in human renal epithelial cells
to attenuate TGF-β signaling [… epithelial cells exerts diverse effects during renal fibrosis and …

Benefical therapeutic effect of Chinese herbal xinji′ erkang formula on hypertension-induced renal injury in the 2-kidney-1-clip hypertensive rats

L Huang, C Pan, T Yu, K Guo, X Wang, J Zhang… - African Journal of …, 2014 - ajol.info
fibrosis were attenuated. XJEK also decreased SCR, BUN, urinary proteins in 24h urine, serum
Ang II and TGF-β 1 concentrations and the intra-renal TGF-β … The protective effect is most …

Plant flavonoids on oxidative stress-mediated kidney inflammation

S Alsawaf, F Alnuaimi, S Afzal, RM Thomas… - Biology, 2022 - mdpi.com
… Flavonoids exert protective effects by decreasing the excessive ROS level or activating …
attenuates hyperuricemia-induced kidney injury by modulating STAT3 and TGF-β signaling