… with this E3 ubiquitin ligase complex is involved in induction of G2 cell cycle arrest. … role of
DDB1-CUL4A VPRBP E3 ubiquitin ligase in the induction of G2 cell cycle arrest by Vpr. DDB1 …

… HIV-1 Vpr-mediated G 2 cell cycle arrest is dependent on the interaction of Vpr with an E3
ubiquitin ligase … activation of the SLX4 complex is involved in the Vpr-mediated G 2 arrest [45]. …

… Rather, HIV-1 Vpr mediated CRL4 recruitment has different … adaptor for cullin 4 E3 ubiquitin
ligase to enable macrophage … virus type 1 Vpr-mediated G2 arrest requires Rad17 and …

… Vpr-mediated G 2 cell cycle arrest is unlikely to involve a suppression of the CRL4A E3
ligase … in DCAF1 are crucial for Vpr-mediated G 2 cell cycle arrest, as a truncated DCAF1 that …

… , suggesting that additional events are involved. In this context, … du complexe E3 ubiquitine
ligase DDB1-CUL4AVprBP, s’… by siRNA impaired Vpr-mediated induction of G2 arrest. …

… HIV-1 Vpr uses the adaptor function of DCAF1 to assemble … to HIV-2 infection requires
the presence of both DCAF1-… factor targeted by Vpr, which induces cell cycle arrest (33, 44), …

… cells is the induction of cell-cycle arrest in G2–M phase 7,8 . … molecular mechanism underlying
HIV-1 Vpr-mediated UNG2 … by HIV-1 Vpr to antagonize UNG2: one involves degradation …

… ► HIV-1 Vpr induces a G2 cell cycle arrest. ► Vpr-mediated G2 arrest requires
engagement of Vpr to the CRL4A (DCAF1) … the DDB1-CUL4AVPRBP E3 ubiquitin ligase …

… of G 2 /M arrest. Infection of T lymphocytes with HIV-1, but not with HIV-1 lacking Vpr, …
Our results suggest that Vpr is targeted to the centrosome where it hijacks a ubiquitin ligase, …

… have previously shown that HIV-1 Vpr is also able to recruit a ubiquitin ligase complex, but
the … a series of complex and successive events are involved in Vpr-mediated SLX4 activation. …