High immunogenicity of nicotine vaccines obtained by intradermal delivery with safe adjuvants
X Chen, M Pravetoni, B Bhayana, PR Pentel, MX Wu - Vaccine, 2012 - Elsevier
… to significantly improve nicotine vaccine immunogenicity by a combination of safe cutaneous
… nicotine entry. ► We present a novel strategy to improve nicotine vaccine immunogenicity. …
… nicotine entry. ► We present a novel strategy to improve nicotine vaccine immunogenicity. …
Effect of adjuvant release rate on the immunogenicity of nanoparticle-based vaccines: a case study with a nanoparticle-based nicotine vaccine
… slow adjuvant release rate induced a significantly higher anti-… (21,24,27) Therefore, in this
study, blood was collected from … The safety of NanoNicVac with different adjuvant release rates …
study, blood was collected from … The safety of NanoNicVac with different adjuvant release rates …
[HTML][HTML] Alternative methods of vaccine delivery: an overview of edible and intradermal vaccines
E Criscuolo, V Caputo, RA Diotti, GA Sautto… - Journal of immunology …, 2019 - hindawi.com
… adjuvant in the vaccine formulation or using sufficiently high … in tobacco plants (Nicotiana
benthamiana) for injectable … the safety and immunogenicity of a large number of intradermal …
benthamiana) for injectable … the safety and immunogenicity of a large number of intradermal …
New directions in nicotine vaccine design and use
PR Pentel, MG LeSage - Advances in pharmacology, 2014 - Elsevier
… to vaccination or passive immunization if the long-term safety … to use strong or experimental
adjuvants that are not suitable … It is likely that sufficiently immunogenic nicotine vaccines will …
adjuvants that are not suitable … It is likely that sufficiently immunogenic nicotine vaccines will …
[PDF][PDF] Evaluating the immunogenicity of an intranasal vaccine against nicotine in mice using the Adjuvant Finlay Proteoliposome (AFPL1)
NL Fraleigh, J Boudreau, N Bhardwaj, NF Eng… - Heliyon, 2016 - cell.com
… adjuvant delivery system using particle assembly strategies for use as an intranasal nicotine
vaccine… , it was the conjugate nicotine vaccine that produced the highest levels of IL-β from …
vaccine… , it was the conjugate nicotine vaccine that produced the highest levels of IL-β from …
Current status of nicotine vaccines: A narrative review
SB Méndez, A Salazar-Juárez - Vacunas (English Edition), 2018 - Elsevier
… with these vaccines formulated with Freund's adjuvant was … higher antibody titres than those
obtained with the vaccine … safety, tolerability and immunogenicity of the NicQb vaccine in …
obtained with the vaccine … safety, tolerability and immunogenicity of the NicQb vaccine in …
Emerging adjuvants for intradermal vaccination
X Chen - International Journal of Pharmaceutics, 2023 - Elsevier
… adjuvants with a good local safety to boost intradermal … Although intradermal delivery
improves vaccine immunogenicity, the … adjuvant was found to also enhance intradermal nicotine …
improves vaccine immunogenicity, the … adjuvant was found to also enhance intradermal nicotine …
Intranasal delivery of a nicotine vaccine candidate induces antibodies in mouse blood and lung mucosal secretions that specifically neutralize nicotine
… improving the immunogenicity of nicotine vaccine candidates … that MPL can be used safely
to induce strong specific mucosal … as a nicotine hapten carrier and MPL as an adjuvant to test …
to induce strong specific mucosal … as a nicotine hapten carrier and MPL as an adjuvant to test …
Novel approaches for the design, delivery and administration of vaccine technologies
J Wallis, DP Shenton, RC Carlisle - Clinical & Experimental …, 2019 - academic.oup.com
… yellow fever) or intradermally [eg bacillus … vaccines tend to be less immunogenic than when
they are present on the surface of a pathogen, thus they require the inclusion of an adjuvant …
they are present on the surface of a pathogen, thus they require the inclusion of an adjuvant …
Enhancing immunogenicity of a 3′ aminomethylnicotine-DT-conjugate anti-nicotine vaccine with CpG adjuvant in mice and non-human primates
MJ McCluskie, DC Pryde, DP Gervais, DR Stead… - International …, 2013 - Elsevier
… anti-nicotine vaccines that utilize nicotine-derived haptens … , especially when a delivery system
such as an aluminum salt is … candidate vaccines not just on ability to induce high antibody …
such as an aluminum salt is … candidate vaccines not just on ability to induce high antibody …