Implantation of AtT-20 or genetically modified AtT-20/hENK cells in mouse spinal cord induced antinociception and opioid tolerance

HH Wu, GL Wilcox, SC McLoon - Journal of Neuroscience, 1994 - Soc Neuroscience
… of AtT-20/hENK cells. The results of this study showed that intrathecally implanted AtT-20
or AtT-20/hENK cells had an antinociceptive effect when secretion from the cells was …

Antinociception following implantation of AtT-20 and genetically modified AtT-20/hENK cells in rat spinal cord

HH Wu, SC McLoon, GL Wilcox - Neural Plasticity, 1993 - hindawi.com
… that isoproterenolproduced antinociception in rats implanted with AtT-20 or AtT-20/hENK
observed that mice receiving AtT-20 cell implants developed tolerance to opioids (it)/43/. Rats …

Cell and gene therapy in the treatment of pain

D Fink, M Mata, JC Glorioso - Advanced drug delivery reviews, 2003 - Elsevier
… an isoproterenol-stimulated antinociceptive effect that was dose … modified AtT-20/hENK cell
implants developed tolerance to the … Genetically modified AtT-20/hENK cell implants, but not …

Gene Transfer in the Treatment of Pain

D Fink, M Mata, J Glorioso - Progress in Neurological Surgery, 2005 - books.google.com
… , and AtT-20/hENK cells, an AtT-20 cell line transfected with the … and-endorphin, implanted
into the mouse subarachnoid space … Genetically modified AtT-20/hENK cell implants, but not …

Cellular implantation for the treatment of chronic pain

J Sagen, M Eaton - Pain, 2003 - taylorfrancis.com
Antinociception following implantation of AtT-20 and genetically modified AtT-20/hENK
cells in rat spinal cord. J Neural … cells in mouse spinal cord induced antinociception and …

Transplants of adrenal medullary chromaffin cells reduce forelimb and hindlimb allodynia in a rodent model of chronic central pain after spinal cord hemisection injury

BC Hains, KM Chastain, AW Everhart, DJ McAdoo… - Experimental …, 2000 - Elsevier
… To reduce allodynia, it would be desirable to implant a permanent … cells (AM), which secrete
catecholamines and opioid peptides, both antinociceptive substances, near the spinal cord. …

Antinociceptive effect of a genomic herpes simplex virus-based vector expressing human proenkephalin in rat dorsal root ganglion

JR Goss, M Mata, WF Goins, HH Wu, JC Glorioso… - Gene therapy, 2001 - nature.com
… of opioids is the dorsal horn of spinal cord where opioid … HSV vector genome, with insertion
of the proenkephalin gene … using the AtT-20 pituitary tumor-derived cell line modified to …

Cell therapy for neuropathic pain in spinal cord injuries

M Eaton - Expert Opinion on Biological Therapy, 2004 - Taylor & Francis
… Other studies with implantation of tumourderived cell lines, such as AtT-20 [46], Neuro2A […
murine cell lines genetically engineered to synthesise and secrete potentially antinociceptive

Gene therapy for pain

G Davar - Gene Therapy for Neurological Disorders and Brain …, 1997 - Springer
… , GL, and McLoon, SC (1994) Implantation of AtT-20 or genetically modified AtT-20/hENK
cells in the mouse spinal cord induced antinociception and opioid tolerance. J. Neurasci. …

[PDF][PDF] GENE THERAPY IN THE MANAGEMENT OF PAIN: AReview 14 RC 3

F David - Citeseer
cells in mouse spinal cord induced antinociception and … , and Wilcox, GL Antinociception
following implantation of AtT-20 and genetically modified AtT-20/hENK cells in rat spinal cord. J …