… study was to use in silico and in vitro techniques to evaluate whether a triple formulation
of antiretroviral drugs (tenofovir, darunavir, and dapivirine) interacted with P-glycoprotein (P-gp) …

… key transporters including P-glycoprotein. Concentrations of … In this study, the concentrations
of darunavir in rectal tissues … of tenofovir, darunavir, and dapivirine on expression of drug …

… recommended to study interaction regarding P-glycoprotein (P-… For example, tenofovir, a
substrate of the efflux transporter … impact on the active transport of darunavir or maraviroc [60]. In …

… that darunavir was a substrate for the P-glycoprotein efflux drug transporter in colorectal
mucosa… of tenofovir, darunavir and dapivirine. Efflux ratios indicated that the permeability of each …

… , ileum, and colon), limiting the absorption of drug substrates from the gastrointestinal tract;
bile … , showing that darunavir and dapivirine were P-gp substrates, while tenofovir presented a …

… capable of enhancing the solubility of darunavir/ritonavir (DRV/r) [… and enzymes such as
P-glycoprotein and cytochrome P450 [… containing dapivirine and MVC found that only dapivirine, …

… drug resistance, such as overcoming P-glycoprotein efflux in … RTIs such as tenofovir (and its
prodrug form, TDF) and dapivirine … A topical 1% tenofovir gel formulated for rectal application …

… transporters, especially for P-glycoprotein (P-gp), breast 28 … To further test the utility our
transporter KO model, … those in vitro KO models, we clearly examined the interaction of 3 PIs with …

… However, clinical data on a dapivirine vaginal ring showed … In vitro drug release tests were
performed in SVF (pH 4.2) (24… of TFV across Caco-2 colorectal cell monolayers in solutions (P …

… plus raltegravir and darunavir/ritonavir offered favorable … (CYP) 3A4 and P-glycoprotein,
while other compounds that … vaginal ring containing dapivirine 25 mg, the incidence of HIV-1 …