… cytotoxicity triggered by perifosine, bortezomib and lenalidomide as single agents as well
as by perifosine combined with bortezomib in different cell lines originating from hematological …

… et al (2010) In vitro cytotoxicity of the novel antimyeloma agents perifosine, bortezomib and
lenalidomide against different cell lines… Invest New Drugs 2010 Nov 16 [Epub ahead of print]. …

… for the development of novel anti-myeloma agents, with emphasis … was active against
bortezomib-resistant MM cell lines, as … perifosine in combination with low-dose Dex 76 , …

… This blockade by perifosine and bortezomib of both Akt and … I study of perifosine in combination
with lenalidomide and … inhibit the growth of MM cell lines and primary myeloma samples …

… anti-MM agents (bortezomib (BRZ) and lenalidomide (LEN), as … anti-myeloma agents,
such as proteosome inhibitors or IMiDs, as well as the novel oral alkylophospholipid perifosine (…

… of thalidomide, bortezomib, and lenalidomide not only transformed … in vitro studies with MM
cell lines and primary tumor cells, … of perifosine in combination with Dex, bortezomib, and/or …

… drugs, such as thalidomide, lenalidomide, and bortezomib. … myeloma, both in cell lines
and freshly isolated patient samples. … the effect of conventional antimyeloma agents in vitro; …

… which generates significant preclinical anti-myeloma activity that is … trial of bortezomib versus
bortezomib with perifosine in … the growth of MM cell lines and primary myeloma samples at …

… A number of HSP90 inhibitors have shown antimyeloma activity in human MM cell lines and
… perifosine with bortezomib, with or without dexamethasone, or perifosine with lenalidomide …

… Interestingly, some cell lines were more responsive to … Lenalidomide is an IMiD that exerts
its anti-myeloma activity through … that perifosine enhances the cytotoxicity of bortezomib and …