In vitro pharmacological activity of the tetrahydroisoquinoline salsolinol present in products from Theobroma cacao L. like cocoa and chocolate

MF Melzig, I Putscher, P Henklein, H Haber - Journal of …, 2000 - Elsevier
pharmacological effects of (S)-salsolinol, it is our interpretation that the consumption of
chocolate by the P rats resulted in enhancement of endogenous concentration of salsolinol with …

Bioactive Compounds in Native Cocoa (Theobroma cacao L.)

R Rojas, B Cabanillas, R Portales… - Native Crops in Latin …, 2022 - taylorfrancis.com
… foods like cheese, yogurt, bread, wine, and chocolate. These compounds possess various
biological activities including … Salsolinol is a tetrahydroisoquinoline that can be found in …

Theobromine and the pharmacology of cocoa

BB Fredholm, HJ Smit - Methylxanthines, 2011 - Springer
… plays in the pharmacological activity of chocolate – the main … pharmacologically active
substances present in chocolate … to play a role in why we like chocolate over and above its innate …

[HTML][HTML] Mood components in cocoa and chocolate: the mood pyramid

E Tuenter, K Foubert, L Pieters - Planta medica, 2018 - thieme-connect.com
… from the fruits of the cocoa tree Theobroma cacao, have a long-… Salsolinol can be present
as a racemate in cocoa and … level, the tetrahydro-isoquinoline alkaloids, more in particular …

[HTML][HTML] Anti-inflammatory and anti-nociceptive effects of cocoa: a review on future perspectives in treatment of pain

M De Feo, A Paladini, C Ferri, A Carducci, R Del Pinto… - Pain and Therapy, 2020 - Springer
… of biological activities, including anti-inflammatory and analgesic … This tetrahydroisoquinoline
alkaloid is a dopaminergic active … The analgesic action of salsolinol seems to also involve a …

Role of acetaldehyde in tobacco smoke addiction

R Talhout, A Opperhuizen… - European …, 2007 - Elsevier
… these effects are also present at concentrations found in … potential via tetrahydroisoquinolines
(TIQs, eg salsolinol) and β-… The relevancy of biological effects exerted by salsolinol via …

The effect of cocoa-rich products on depression, anxiety, and mood: A systematic review and meta-analysis

L Fusar-Poli, A Gabbiadini, A Ciancio… - Critical reviews in …, 2022 - Taylor & Francis
Chocolate and cocoa are products derived from cocoa beans, the seeds of the Theobroma
cacaoCocoa is a complex food and contains several biological compounds. Of note, during …

[HTML][HTML] Salsolinol—neurotoxic or Neuroprotective?

M Kurnik-Łucka, G Latacz, A Martyniak, A Bugajski… - Neurotoxicity …, 2020 - Springer
… role of (RS)-salsolinol in the mood effects of cocoa. The D 3 -… racemate) was sufficient to
reach a pharmacologically relevant … (RS)-salsolinol is one of the many tetrahydroisoquinoline

Neuroprotective Activity of Enantiomers of Salsolinol and N-Methyl-(R)-salsolinol: In Vitro and In Silico Studies

M Kurnik-Łucka, G Latacz, A Bucki, M Rivera-Meza… - ACS …, 2023 - ACS Publications
Salsolinol (1-methyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol) … Clearly, in vitro, SAL also exerts
its biological action in a dose-… are present in vivo, (2) about 3% of NMSAL was found to be …

A perspective on natural products research and ethnopharmacology in Mexico: the eagle and the serpent on the prickly pear cactus

M Heinrich, B Frei Haller, M Leonti - Journal of Natural Products, 2014 - ACS Publications
… dopamine-related tetrahydroisoquinoline salsolinol (3, 4) was found in chocolate and cocoa
up to a … microdialysis study showed that at high concentrations both salsolinol enantiomers (…