… Phosphorus MRS was evaluated as a monitor of … herpes simplex virus thymidine kinase
suicide gene therapy paradigm. I n vivo 31P spectra were obtained from subcutaneous rat C6 …

… describe the BT4C rat glioma model for the evaluation of the effectiveness … vivo 31P MRS
evaluation of ganciclovir toxicity in C6 gliomas stably expressing the herpes simplex thymidine …

… therapy, in which the genes for toxic products are transduced … thymidine kinase gene of
herpes simplex virus-1: implication for … kinase/ganciclovir administration system by ponicidin. …

… are toxic to mammalian cells, can influence the expression of … The herpes simplex virus 1
thymidine kinase (TK) and … the conversion of the nontoxic prodrugs ganciclovir and 5-fluoro-…

… The HSVl—tk gene expresses a viral thymidine kinase (note … —tk expression,”38 and, as
such, toxicity to tk expressing cells … expression in mice with radiolaf beled ganciclovir.] Nucl Med …

… following recombinant adenoviral-mediated transfer of the herpes simplex virus thymidine
kinase gene by … vivo 31P MRS evaluation of ganciclovir toxicity in C6 gliomas stably ex- …

… in vitro transfer of the herpes simplex virus thymidine kinase gene (HSVtk) into rat C6 glioma
… 12 days of ganciclovir treatment (/}()UOIl1) as shown in Fig. 12. No significant differences in …

… of the gene encoding HSV thymidine kinase (HSVtk) to activate the prodrug ganciclovir (GCV)
in a model of rat prostate cancer MRS … Assessment of ganciclovir toxicity to experimental …

… Herpes Simplex Virus type 1 thymidine kinase (HSVtk) gene … post treatment with ganciclovir
(GCV, 15 mg/kg ip, twice-daily). … into the biochemical mechanisms of toxicity of an individual …

… In vivo 31P MRS evaluation of ganciclovir toxicity in C6 gliomas stably expressing the
herpes simplex thymidine kinase gene. NMR Biomed 9, 364 – 368. …