Inhibition of Src kinase blocks high glucose–induced EGFR transactivation and collagen synthesis in mesangial cells and prevents diabetic nephropathy in mice
K Taniguchi, L Xia, HJ Goldberg, KWK Lee, A Shah… - Diabetes, 2013 - Am Diabetes Assoc
… that high glucose induced mesangial cell EGFR transactivation through Src kinase stimulation.
… In summary, Src activation occurs in mesangial cells exposed to high glucose and in the …
… In summary, Src activation occurs in mesangial cells exposed to high glucose and in the …
Collagen I induction by high glucose levels is mediated by epidermal growth factor receptor and phosphoinositide 3-kinase/Akt signalling in mesangial cells
D Wu, F Peng, B Zhang, AJ Ingram, B Gao… - Diabetologia, 2007 - Springer
… that EGFR–PI3K–Akt signalling mediates high glucose-induced … is the pathogenic hallmark
of diabetic renal disease, we studied … whether EGFR transactivation might play a role in high …
of diabetic renal disease, we studied … whether EGFR transactivation might play a role in high …
Novel epidermal growth factor receptor inhibitor attenuates angiotensin II–induced kidney fibrosis
… , diabetic nephropathy, hypertensive nephropathy, and glomerulonephritis … transactivation
of EGFR by high glucose leads to collagen synthesis in mesangial cells, and EGFR inhibition …
of EGFR by high glucose leads to collagen synthesis in mesangial cells, and EGFR inhibition …
Src family kinases in chronic kidney disease
J Wang, S Zhuang - American Journal of Physiology-Renal …, 2017 - journals.physiology.org
… This study highlights the importance of Src in diabetic nephropathy. Mesangial cell
proliferation is an important pathological phenomenon in DN (81). High glucose induced the …
proliferation is an important pathological phenomenon in DN (81). High glucose induced the …
[图书][B] High glucose-induced ROS production is mediated by c-Src in mesangial cells
KWK Lee - 2011 - search.proquest.com
… isozymes implicated in diabetic kidney disease as evidenced by … revealed that inhibition of
Src with chemical inhibitors blocked … of a Src inhibitor to STZ-injected diabetic mice inhibited …
Src with chemical inhibitors blocked … of a Src inhibitor to STZ-injected diabetic mice inhibited …
HB-EGF release mediates glucose-induced activation of the epidermal growth factor receptor in mesangial cells
L Uttarwar, F Peng, D Wu, S Kumar… - American Journal …, 2011 - journals.physiology.org
… is a hallmark of diabetic nephropathy. We showed that … inhibitors of the most common
potential mediators of EGFR … of ADAM17 in glucose-induced EGFR transactivation, we assessed …
potential mediators of EGFR … of ADAM17 in glucose-induced EGFR transactivation, we assessed …
Mefunidone ameliorates diabetic kidney disease in STZ and db/db mice
Y Jiang, F Xie, X Lv, S Wang, X Liao, Y Yu… - The FASEB …, 2021 - Wiley Online Library
… in diabetic nephropathy and elucidate its possible mechanism. … Inhibition of Src kinase
blocks high glucose-induced EGFR transactivation and collagen synthesis in mesangial cells …
blocks high glucose-induced EGFR transactivation and collagen synthesis in mesangial cells …
Connexin43 regulates high glucose-induced expression of fibronectin, ICAM-1 and TGF-β1 via Nrf2/ARE pathway in glomerular mesangial cells
Z Chen, X Xie, J Huang, W Gong, X Zhu, Q Chen… - Free Radical Biology …, 2017 - Elsevier
… Diabetic nephropathy (DN) is one of the most serious microvascular … -Src is sensitive to
oxidative stress, and inhibition of c-Src activity blocks high glucose-induced EGFR transactivation …
oxidative stress, and inhibition of c-Src activity blocks high glucose-induced EGFR transactivation …
EGF receptor deletion in podocytes attenuates diabetic nephropathy
… diabetic mice compared with the EGFR podKO diabetic mice (… inhibition of c-Src kinase
prevented progression of diabetic … high-glucose–induced TGFβ-Smad2/3 signaling activation and …
prevented progression of diabetic … high-glucose–induced TGFβ-Smad2/3 signaling activation and …
High glucose up-regulates ADAM17 through HIF-1α in mesangial cells
R Li, L Uttarwar, B Gao, M Charbonneau, Y Shi… - Journal of Biological …, 2015 - ASBMB
… showed that ADAM17 mediates high glucose-induced matrix production by kidney … inhibition
thus provides a potential novel therapeutic strategy for the treatment of diabetic nephropathy…
thus provides a potential novel therapeutic strategy for the treatment of diabetic nephropathy…