Interactions of VEGF isoforms with VEGFR-1, VEGFR-2, and neuropilin in vivo: a computational model of human skeletal muscle
FM Gabhann, AS Popel - American Journal of Physiology …, 2007 - journals.physiology.org
… the proangiogenic activation of VEGF receptors (VEGFRs) by VEGF family members in
skeletal muscle, we develop a computational model of VEGF isoforms (VEGF 121 , VEGF 165 ), …
skeletal muscle, we develop a computational model of VEGF isoforms (VEGF 121 , VEGF 165 ), …
Differential binding of VEGF isoforms to VEGF receptor 2 in the presence of neuropilin-1: a computational model
F Mac Gabhann, AS Popel - American Journal of …, 2005 - journals.physiology.org
… a computational model of the interactions between NRP1 and … complexes by the isoforms
VEGF 121 and VEGF 165 . We … computational models of endothelial cell behavior in in vitro …
VEGF 121 and VEGF 165 . We … computational models of endothelial cell behavior in in vitro …
A computational analysis of in vivo VEGFR activation by multiple co-expressed ligands
LE Clegg, F Mac Gabhann - PLoS computational biology, 2017 - journals.plos.org
… -specific phosphorylation in vivo, mediated by Neuropilin-1. These … -developed computational
models of VEGF distribution and … VEGF production by skeletal muscle; or degradation of …
models of VEGF distribution and … VEGF production by skeletal muscle; or degradation of …
Formation of VEGF isoform-specific spatial distributions governing angiogenesis: computational analysis
P Vempati, AS Popel, F Mac Gabhann - BMC systems biology, 2011 - Springer
… release regulate VEGF diffusion in vivo are therefore not yet … VEGF isoforms also differentially
bind to neuropilin-1 and -2 (… diffusion-based computational model of VEGF transport. The …
bind to neuropilin-1 and -2 (… diffusion-based computational model of VEGF transport. The …
Systems biology of vascular endothelial growth factors
FM Gabhann, AS Popel - Microcirculation, 2008 - Taylor & Francis
… Computational models of VEGF transport in vitro and in vivo have been created for the
study … Using computational models of human breast cancer, we have shown that neuropilin …
study … Using computational models of human breast cancer, we have shown that neuropilin …
Molecular pharmacology of VEGF-A isoforms: binding and signalling at VEGFR2
… bioavailability and interaction with the co-receptor Neuropilin-1. … both in vitro and in vivo
experimental evidence, VEGF xxx a … Computational modelling of systems pharmacology have …
experimental evidence, VEGF xxx a … Computational modelling of systems pharmacology have …
A two-compartment model of VEGF distribution in the mouse
… results, a computational model of VEGF distribution in the … receptors VEGFR-1, VEGFR-2,
and co-receptor neuropilin-1. … human VEGFR-1 to the third Ig domain of human VEGFR-2 …
and co-receptor neuropilin-1. … human VEGFR-1 to the third Ig domain of human VEGFR-2 …
Computational kinetic model of VEGF trapping by soluble VEGF receptor-1: effects of transendothelial and lymphatic macromolecular transport
FTH Wu, MO Stefanini, F Mac Gabhann… - Physiological …, 2009 - journals.physiology.org
… We previously developed a computational model for predicting … Interactions of VEGF isoforms
with VEGFR-1, VEGFR-2, and neuropilin in vivo: a computational model of human skeletal …
with VEGFR-1, VEGFR-2, and neuropilin in vivo: a computational model of human skeletal …
VEGF-A121a binding to Neuropilins–A concept revisited
S Sarabipour, F Mac Gabhann - Cell Adhesion & Migration, 2018 - Taylor & Francis
… tyrosine kinases VEGFR-1 and VEGFR-2. We focus here on … This evidence suggests that, in
vitro, VEGF-A121a can bind … cells in vitro suggests that these components are interacting (or …
vitro, VEGF-A121a can bind … cells in vitro suggests that these components are interacting (or …
A compartment model of VEGF distribution in humans in the presence of soluble VEGF receptor-1 acting as a ligand trap
… co-receptor neuropilin-1 (NRP1), as well as sVEGFR1. The … computational models of the in
vivo biochemical interactions … entire 65 kg as homogenous skeletal muscle with a density of …
vivo biochemical interactions … entire 65 kg as homogenous skeletal muscle with a density of …