… of signaling pathways. We have discovered that the endocytic scaffolding protein intersectin
(ITSN) cooperated with epidermal growth factor receptor (EGFR) in the regulation of cell …

… of the SH3 domains of ITSN1 blocks epidermal growth factor-mediated Ras activation and
… ITSN1 promotes the ubiquitylation and degradation of the epidermal growth factor receptor (…

… ubiquitylation represents a critical step in cellular signaling. … clathrin-dependent endocytosis,
ITSN1 regulates a number of … ubiquitylation of the epidermal growth factor receptor (EGFR), …

… ITSN regulates the internalization and signalling of activated EGFR and has been … stimulate
ubiquitination and subsequent degradation of EGFR thereby dampening EGFR signalling 36…

… Cbl-mediated EGFR ubiquitylation is regulated by several Cbl-… of EGFR ubiquitylation and
control of cell signaling. … The requirement of ubiquitylation for receptor internalization is still a …

… controls its trafficking. This review highlights the current understanding of an intersection
between EGFR signalling … potential role of ubiquitylation in EGFR endocytosis has been widely …

… ITSN1 stimulates ubiquitylation of the epidermal growth factor receptor (EGFR) through …
of signaling by RTKs are determined by trafficking of these receptors following endocytosis. …

… coordinate distinct steps in receptor endocytosis and cell signalling have been identified.
In … the ubiquitylation and degradation of the activated epidermal growth factor receptor (EGFR). …

… the epidermal growth factor receptor (EGFR), Ras, and PI3KC2β. This review will discuss
recent findings on ITSN’s role in regulating these signal … Ubiquitylation and endocytosis play …

… the role of INSTNs in viral endocytosis by interaction with signalling pathways. INSTN-2 …
enhancing ubiquitylation of EGFR by ubiquitin E3 ligase Cbl due to growth factor stimulation [25]. …