… eyc could reflect melanin formation. Our finding that all or almost all dopa and 5-S-cysteinyldopa
is present in the cytoplasm favour the hypothesis that these pigment precursors. when …

… ), suggests that, at least in melanoma cells, the intracellular y-GTP … in comparison with
non-pigment cell tumors and its urinary … dopa-loading on glutathione-dependent 5-S-cysteinyldopa …

… concentration of dopa was 0.9 pM and of 5-S-cysteinyldopa was … The intracellular metabolism
of cysteine is highly integrated … 5-Scysteinyldopa is constantly present in melanin-forming …

… melanoma cell lines and related to the 5SCD levels, pigment and … (PB-DOPA) is formed when
hydroxyl radicals react with … , such as UV exposure, pigmentation may also proceed by the …

… physiology of the cells as revealed by growth and pigmentation. It was … 5-S cysteinyldopa
in malignant melanoma in vivo: Produc- tion, excretion and regulatory factors, in Pigment cell …

… Results of the determination of 5-S-cysteinyldopa and DOPA in … No pigmentation Was
observed on the cut surfaces. The … cells with minimal pigment formation, only melanosomal …

… pigment cells by modulating the levels of substrates and by the use of specific inhibitors. We
also studied the intracellular … inhibit dopa-glutathione dependent 5-S·cysteinyldopa genesis …

… 5-S-cysteinyldopa in the urine of melanoma patients. 5-S-Cysteinyldopa is now widely used
as … renal clearance, make 5-S-cysteinyldopa a useful marker of pigmentation in normal and …

… Pigmentation of hair, skin and eyes in animals mainly … and degradation of melanin pigments
are not covered in this … adducts of dopa (cysteinyldopas) among which 5-S-cysteinyldopa (5-…

… in extracellular proteins, PB-DOPA and other DOPA-polymers … , and the pigment epithelial
cells of the retina. Melanins contain … protein the main product is 5-S-cysteinyldopa (5SCD) [36]. …