… of long-lived Ghrhr mutant mice reports that increased bile acid … to xenobiotic stress, possibly
contributing to longevity. … and intracellular signaling pathways that control longevity and …

… Regulation of longevity by bile acids was first observed in Little mice, … The increased levels
of bile acids in these long-lived mice … Increased total bile acid levels have also been observed …

… acid supplementation shortened the lifespan of long-lived daf-… is “proaging” in response to
signals from the dauer pathways. … in long-lived Ames dwarf mice, rate-limiting enzymes for bile …

… /− mice (95), it is still not fully established how FXR signaling keeps hepatic fat deposits in
check. While a comparative study in liver- and intestine-specific Fxr −/− mice demonstrate that …

… in lifespan (50% and 25%, respectively) when compared with their wild-type siblings. To gain
further insight into the molecular basis for the extended longevity of these mice, … of signal …

… GH signaling during development on longevity, we re-examine this issue in both sexes of
normal and longlived mutant mice. … Bile acids induce the expression of the human peroxisome …

… bile acid–like steroid dafachronic acid extends life span through nuclear receptor
signaling. In the … Long-lived dwarf mice: Are bile acids a longevity signal? Aging Cell 2007;6:421–423. …

… instead that bile acids and the primary bile acid receptor Fxr (… with increased longevity in
a variety of long-lived mutants in … Importantly, bile acids also function as signaling molecules …

… of BAs as potential longevity signaling molecules, and may … deficiency and longevity is
derived from Laron dwarf mice, … IGF-1 in life span regulation is supported by long-lived IGF-1 …

… GHRH knockout mice are remarkably long-lived, exhibiting major … KO mice feature
perturbations in a network of signaling pathways … Some studies have shown elevation of bile acids …