MCP2 activates NFκB signaling pathway promoting the migration and invasion of ESCC cells

J Zhou, S Zheng, T Liu, Q Liu, Y Chen… - Cell biology …, 2018 - Wiley Online Library
… Although we firstly reported that MCP2 can activate the NF-κB signaling pathway, promoting
the migration and invasion of ESCC cells and inducing EMT process. There were, however, …

IQGAP1 enhances cell invasion and matrix metalloproteinase-2 expression through upregulating NF-κB activity in esophageal squamous cell carcinoma cells

Z Zhang, Y Wei, X Li, R Zhao, X Wang, Z Yang, T Li… - Gene, 2022 - Elsevier
promotion role to regulate the migration and invasion of … in the growth, migration and invasion
of ESCC cells, and further … on cellular malignant phenotypes are through activating NF-κB, …

TAB3 promotes human esophageal squamous cell carcinoma proliferation and invasion via the NFκB pathway

J Zhao, L Gai, Y Gao, W Xia, D Shen… - Oncology …, 2018 - spandidos-publications.com
… of TAB3 on the migration and invasion of ESCC cells. Wound healing … activation of the NF-κB
pathway (15,16). The present study analyzed the TAB3-TAK1-NF-κB pathway in ESCC cells

[HTML][HTML] MiR-345-5p functions as a tumor suppressor in pancreatic cancer by directly targeting CCL8

T Mou, F Xie, P Zhong, H Hua, L Lai, Q Yang… - Biomedicine & …, 2019 - Elsevier
promote the invasion and migration of esophageal squamous cell carcinoma cells by the
activating NF-κB signaling … inhibitor of NF-κB, might directly promote the transcription of MCP2/…

XPD inhibits cell growth and invasion and enhances chemosensitivity in esophageal squamous cell carcinoma by regulating the PI3K/AKT signaling pathway

J Jian, S Li, LZ Liu, L Zhen, L Yao… - International …, 2020 - spandidos-publications.com
… mitogen‑activated protein kinase (MAPK) signaling pathway‑… invasion of EC9706 and
EC109 cells, whilst also enhancing … and other signaling pathways in ESCC, such as the NF-κB, …

Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy

AA Bhat, S Nisar, S Maacha, TC Carneiro-Lobo… - Molecular cancer, 2021 - Springer
… Monocyte Chemotactic Protein (MCP2 alias CCL8) secreted from M2 macrophages activates
the NF-κB pathway and promotes migration and invasion of ESCC cells, thereby inducing …

Hypoxia-induced ZEB1 promotes cervical cancer progression via CCL8-dependent tumour-associated macrophage recruitment

XJ Chen, YR Deng, ZC Wang, WF Wei, CF Zhou… - Cell Death & …, 2019 - nature.com
… the migration-related NF-κB, AKT, ERK1/2, and p38 signalling pathways. … HIF-1α-induced
EMT and cell invasion 33 . Our study … Activated NF-κB signalling is essential for maintaining the …

ING5 inhibits migration and invasion of esophageal cancer cells by downregulating the IL-6/CXCL12 signaling pathway

Y Wang, J Tan, J Li, H Chen… - Technology in Cancer …, 2021 - journals.sagepub.com
… time that ING5 inhibits ESCC cell migration and invasion by … molecular signaling pathways
in tumor tissues can activate … of ING5 promoted these processes in the NSCLC cell line H1299…

Chemokines and Their Receptors: Predictors of Therapeutic Potential in Tumor Microenvironment on Esophageal Cancer

CG Huang, Q Liu, ST Zheng, T Liu, YY Tan… - Digestive Diseases and …, 2024 - Springer
promoting the progression of ESCC and poor prognosis [26]. It is CCL8 that can activate the
NF-κB signaling pathway… , and promote the migration and invasion of ESCC cells in vitro [27]…

[HTML][HTML] Iron accelerates Fusobacterium nucleatum–induced CCL8 expression in macrophages and is associated with colorectal cancer progression

T Yamane, Y Kanamori, H Sawayama, H Yano, A Nita… - JCI insight, 2022 - ncbi.nlm.nih.gov
promoting chemokine production in macrophages. Our observations indicate a key role for
iron in modulating the NF-κB signaling pathwayNF-κB activation by cellular iron might be cell-…