MEG3 promotes proliferation and inhibits apoptosis in osteoarthritis chondrocytes by miR-361-5p/FOXO1 axis

A Wang, N Hu, Y Zhang, Y Chen, C Su, Y Lv… - BMC Medical …, 2019 - Springer
… To summarize these interactions, a schematic of the expressional patterns of factors in the
MEG3/miR-361-5p/FOXO1 axis and its regulatory effects on OA is showed in Additional file 1: …

LncRNA MEG3 Protects Chondrocytes From IL-1β-Induced Inflammation via Regulating miR-9-5p/KLF4 Axis

Y Huang, D Chen, Z Yan, J Zhan, X Xue, X Pan… - Frontiers in …, 2021 - frontiersin.org
… Background: Osteoarthritis (OA) is a chronic degenerative … and migration and inhibit
apoptosis and inflammation by … matrix via regulating the miR-361-5p/FOXO1 axis (Wang A. et …

Biological functions and applications of LncRNAs in the regulation of the extracellular matrix in osteoarthritis

D Shi, Y Mei, W Hao, J Li, S Liu, X Lin - Frontiers in Cell and …, 2024 - frontiersin.org
… MINCR can promote cell proliferation while inhibiting apoptosis and … stress of chondrocytes
via the miR-222-3p/ADAM10 axis. … that LncRNA MEG3 inhibits chondrogenic differentiation of …

The function of lncRNAs in the pathogenesis of osteoarthritis

CP He, XC Jiang, C Chen, HB Zhang… - Bone & joint …, 2021 - boneandjoint.org.uk
… the miR-361-5p/FOXO1 axis. The expression of MEG3 in human OA chondrocytes was …
signalling pathway to inhibit apoptosis, and promote mesenchymal stem cells (MSC) activity and …

The lncRNA MEG3 downregulation leads to osteoarthritis progression via miR-16/SMAD7 axis

J Xu, Y Xu - Cell & bioscience, 2017 - Springer
… in cartilage tissues of rat OA model, and MEG3 konckdown might lead to promoting proliferation
and inhibiting apoptosis in IL-1β-induced rat chondrocytes through miR-16/SMAD7 axis, …

The emerging role of lncRNAs in osteoarthritis development and potential therapy

X Zhang, Q Liu, J Zhang, C Song, Z Han, J Wang… - Frontiers in …, 2023 - frontiersin.org
MEG3 reduced apoptosis and induced proliferation of chondrocytes via influencing miR-3615p/FoxO1
axis … LncRNA DANCR has been reported to promote proliferation and …

[HTML][HTML] Interactions among lncRNA/circRNA, miRNA, and mRNA in musculoskeletal degenerative diseases

YL Zheng, G Song, JB Guo, X Su, YM Chen… - Frontiers in Cell and …, 2021 - frontiersin.org
… , involving in chondrocyte proliferation and apoptosis, extracellular … /circRNA-miRNA-mRNA
axis in the development of MSDD … people, and MEG3 could inhibit inflammatory responses. …

lncRNA GAS5 suppresses rheumatoid arthritis by inhibiting miR-361-5p and increasing PDK4

W Zhang, B Li, N Xia, L Zhu, Z Zhang, Z Ren… - Biochemical and …, 2021 - Elsevier
… could accelerate chondrocyte proliferation, inhibit apoptosis. … could inhibit LPS-induced
chondrocyte proliferation and apoptosis … Therefore, GAS5/miR-361-3p/PDK4 signaling axis may …

[HTML][HTML] Crosstalk among circRNA/lncRNA, miRNA, and mRNA in osteoarthritis

H Kong, ML Sun, XA Zhang, XQ Wang - Frontiers in Cell and …, 2021 - frontiersin.org
… lncRNA/circRNA-miRNA-mRNA axis in OA, and the possible prospects of … , promotes the
expression of GIT1 and then promotes the proliferation of chondrocytes and inhibits apoptosis, …

PRMT1 promotes extracellular matrix degradation and apoptosis of chondrocytes in temporomandibular joint osteoarthritis via the AKT/FOXO1 signaling pathway

Q Shen, Y Xiao, B Cheng, Z Sun, Y Hu, H Yang… - … International Journal of …, 2021 - Elsevier
… Our results are in line with recent studies suggesting that PRMT1 silencing inhibits IL-1β-induced
chondrocyte apoptosis and that PRMT1 plays a vital role in the change of chondrocyte