… study, we examined the molecular mechanism of activation of procaspase-3 fused with ODD
548–603 , which has VHL-mediated protein destruction motif of HIF-1α containing only 564-…

… , which has VHL-mediated protein destruction motif of HIF1α … of PTDODD fusion protein
as a hypoxia-specific probe, we … “Mechanism of hypoxia-specific cytotoxicity of procaspase-3 …

… fusion with a VHL-mediated protein destruction motif of HIF-1α ODD domain-containing
Pro564 endows the fused protein … an endogenous cytotoxic protein procaspase-3, which is a …

… is degraded by ubiquitination and proteasomal degradation … Pro-564 residue endows the
fused protein with the same … The procaspase-3 domain is an inactive proenzyme form of human …

… of reactive and cytotoxic species, and because radiation-induced DNA damage is fixed
and … As the stability of the ODD-Luc fusion protein is regulated through the same oxygen-…

… We previously reported that a fusion protein containing ODD … protein PTD-ODD 548–603
-procaspase-3 significantly … Many hypoxia-specific probes have been reported, including …

… and act locally; otherwise damage to normal tissues and side … the Tat–ODD fusion protein
with cytotoxicity shows a hypoxia-… the resultant fusion protein, Tat–ODD–procaspase-3 (TOP3), …

… paramagnetic marker that has low toxicity for human is currently … radionuclides ligated with
hypoxia specific compounds that … Because PTD–ODD fusion proteins underlie the same ODD …

… the fusion protein contains a translocation motif (TLM) that is … in-frame fusion site with the
oxygen-dependent degradation … the toxic protein so as to have decreased toxicity and immune …

… We previously reported that a fusion protein containing the … conditions, via a VHL-mediated
protein degradation system, in a … sequences of procaspase-3 in PTD-ODD-procaspase-3 with …