Metabolic profiling reveals disorder of carbohydrate metabolism in mouse fibroblast cells induced by titanium dioxide nanoparticles

C Jin, Y Liu, L Sun, T Chen, Y Zhang… - Journal of Applied …, 2013 - Wiley Online Library
nanoparticles was investigated by analyzing the changes in metabolite profiles both in mouse
fibroblast (L929) cells … GC/TOFMS)-based metabolomic strategy. With multivariate statistics …

Metabolomic analysis on the toxicological effects of TiO2 nanoparticles in mouse fibroblast cells: from the perspective of perturbations in amino acid metabolism

Y Bo, C Jin, Y Liu, W Yu, H Kang - Toxicology mechanisms and …, 2014 - Taylor & Francis
Titanium dioxide nanoparticles (nano-TiO 2 ) have been widely … the disorder of carbohydrate
metabolism induced by nano-… 6 clearly revealed that the abnormal amino acid metabolism

Effect of titanium dioxide nanoparticle on proliferation, drug-sensitivity, inflammation, and metabolomic profiling of human oral cells

R Garcia-Contreras, RJ Scougall-Vilchis… - Nanobiomaterials in …, 2016 - Elsevier
… the proliferation of gingival fibroblasts (possibly for repair … highest cytotoxicity against a
mouse osteoblastic cell line MC3T3-… SE, as well as lignin–carbohydrate complex, shows potent …

Gene expression in liver injury caused by long-term exposure to titanium dioxide nanoparticles in mice

Y Cui, H Liu, Y Ze, Z Zengli, Y Hu, Z Cheng… - Toxicological …, 2012 - academic.oup.com
cell function in human dermal fibroblasts and decreased cell area, cell proliferation, cell
mobility, and the ability of cells to … (A) Control group shows normal hepatic architecture and …

The toxicity of nanoparticles and their interaction with cells: an in vitro metabolomic perspective

M Awashra, P Młynarz - Nanoscale Advances, 2023 - pubs.rsc.org
… that AgNPs caused cell death in L-929 fibroblast cell lines in … levels can change the metabolic
profile of a cell system and vice … Micro-titania (titanium oxide, TiO 2 ) particles are known as …

Copper oxide nanoparticle toxicity profiling using untargeted metabolomics

MSP Boyles, C Ranninger, R Reischl, M Rurik… - Particle and fibre …, 2015 - Springer
… We thus believe that untargeted metabolomics profiling is a suitable tool for NP toxicity …
The metabolomics approach revealed a depletion of the reduced form of glutathione (GSH) and …

Metabolomics analysis of TiO2 nanoparticles induced toxicological effects on rice (Oryza sativa L.)

B Wu, L Zhu, XC Le - Environmental Pollution, 2017 - Elsevier
… concentration of titanium dioxide nanoparticles (nano-TiO 2 ) … -standing approach used for
metabolite profiling, offering a … , metabolic responses to nano-TiO 2 were studied in mouse

GC/TOFMS Analysis of Endogenous Metabolites in Mouse Fibroblast Cells and Its Application in TiO2 Nanoparticle-Induced Cytotoxicity Study

Y Liu, Y Cheng, T Chen, Y Zhang, X Wang, A Zhao… - Chromatographia, 2012 - Springer
… The metabolic profiles of the two groups were further differentiated by an OPLS-DA …
Deregulations of carbohydrate metabolism, fatty acid metabolism, and … cytotoxicity might be …

Mechanoregulation of titanium dioxide nanoparticles in cancer therapy

G Raja, S Cao, DH Kim, TJ Kim - Materials Science and Engineering: C, 2020 - Elsevier
… microenvironmental mechanosensitive metabolism have not … 2 -NPs induced various
mechanical stimuli on tumor cells. The … the context of metabolomics, which shows great promise in …

Predictive metabolomic signatures for safety assessment of metal oxide nanoparticles

L Cui, X Wang, B Sun, T Xia, S Hu - Acs Nano, 2019 - ACS Publications
… LC-MS) based metabolomics was used to reveal significantly … , which defines the metabolic
profile closely linked to a … exposure caused significant reduction of inosine in the mouse lung …