Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation

A Ledeboer, EM Sloane, ED Milligan, MG Frank… - Pain, 2005 - Elsevier
… whether minocycline decreases allodynia in rat models of … pain, and whether the putative
effects of minocycline are associated with decreased expression of proinflammatory cytokines

Analgesic effect of minocycline in rat model of inflammation-induced visceral pain

P Kannampalli, S Pochiraju, M Bruckert… - European journal of …, 2014 - Elsevier
minocycline, a semi-synthetic tetracycline antibiotic, in a rat model of inflammation-induced
visceral pain… Intrathecal minocycline significantly attenuated the VMR to CRD in inflamed rats, …

[HTML][HTML] Involvement of pro-and antinociceptive factors in minocycline analgesia in rat neuropathic pain model

E Rojewska, K Popiolek-Barczyk, AM Jurga… - Journal of …, 2014 - Elsevier
… and formation of proinflammatory cytokines, namely minocycline, … of mechanical allodynia
(A; von Frey test) and CD40 mRNA … Minocycline significantly attenuated the mechanical

Minocycline modulates neuropathic pain behaviour and cortical M1–M2 microglial gene expression in a rat model of depression

NN Burke, DM Kerr, O Moriarty, DP Finn… - Brain, behavior, and …, 2014 - Elsevier
mechanical allodynia in OB rats was attenuated by chronic … Thus, chronic minocycline
attenuates neuropathic pain … activation and release of pro-inflammatory cytokines/mediators, and …

Minocycline attenuates mechanical allodynia and expression of spinal NMDA receptor 1 subunit in rat neuropathic pain model

S Pu, Y Xu, D Du, M Yang, X Zhang, J Wu… - Journal of physiology and …, 2013 - Springer
rat models of pain facilitation have shown that minocycline attenuates mechanical allodynia
and proinflammatory … microglia induces the production of proinflammatory cytokines [18], …

Pain-relieving effectiveness of co-treatment with local tramadol and systemic minocycline in carrageenan-induced inflammatory pain model

T Mert, E Sahin, S Yaman, M Sahin - Inflammation, 2018 - Springer
cytokine levels of paw and spinal cord tissues in a rat model of … , our results suggest that
pro-inflammatory cytokines TNF-α … Inhibition of microglial activation attenuates the development …

Minocycline prevents the development of neuropathic pain, but not acute pain: possible anti-inflammatory and antioxidant mechanisms

SSV Padi, SK Kulkarni - European journal of pharmacology, 2008 - Elsevier
… of pro-inflammatory cytokines and oxidative stress was also evaluated to elucidate mechanism
of action of minocycline in attenuating neuropathic pain… , minocycline attenuated oxidative …

Minocycline as a promising therapeutic strategy for chronic pain

YQ Zhou, DQ Liu, SP Chen, J Sun, XM Wang… - Pharmacological …, 2018 - Elsevier
… component of descending nociceptive facilitation circuitry [40]. … significantly attenuate the
mechanical allodynia in a rat model … stimuli such as pro-inflammatory cytokines, heat shock and …

[HTML][HTML] Systemic lipopolysaccharide-induced pain sensitivity and spinal inflammation were reduced by minocycline in neonatal rats

CT Hsieh, YJ Lee, X Dai, NB Ojeda, HJ Lee… - International journal of …, 2018 - mdpi.com
… (LPS) produced hyperalgesia (pain facilitation), which is possibly … Minocycline attenuated
an LPS-induced increase in the … level and in the central nervous system in our animal model. …

Minocycline and pentoxifylline attenuate allodynia and hyperalgesia and potentiate the effects of morphine in rat and mouse models of neuropathic pain

J Mika, M Osikowicz, W Makuch… - European journal of …, 2007 - Elsevier
… of minocycline in a rat model of neuropathic pain result from: i… Therefore significant facilitation
of motor function recovery, … glial activity and proinflammatory cytokine responses may …