… tight junctions. In contrast, we show that both toxins modified the paracellular permeability
… induced a disorganization of basolateral actin filaments, without modifying apical actin. Both …

… At a higher magnification (×100,000), intercellular junctions, … induce modification of the
intercellular endothelial cell junctions, … the main regulators of the cell barrier integrity; Rho plays a …

… Alteration of E-cadherin intercellular junctions accounts for the increased fluid secretions, …
and intercellular junctions, leading to increased permeability of the intestinal barrier in C. …

… This process probably involves a conformational change and insertion of the toxin into the …
of the intercellular junctions, and thus an increase in cell barrier permeability. Racinactivation …

… of the toxin to endothelial cells of the brain–blood barrier (BBB) … to be a postmortem change
rather than a true lesion [84]. … , the extracellular matrix and intercellular junctions [162]. NetB …

… epithelial tight junctions, including claudins and occludin. This association affects tight junction
structure and function, changing the permeability and … for Clostridium sordellii lethal toxin …

… barrier formed of epithelial cells linked by intercellular junctions including apical tight junctions
and … This dysfunction of cell barrier permeability is thought to contribute to increased fluid …

… and systemic vascular permeability, and death, a process similar to that seen in some C. …
Hela cells were cultivated in Dulbecco’s modified Eagle medium (Gibco) supplemented with 10…

… that the toxins undergo a conformational change triggered by … by the toxins causes the loss
of epithelial barrier function, … , which, in addition to increased paracellular permeability, may …

… Clostridium sordellii is a Gram positive, spore-forming … sordellii was first characterized in
1922 by Alfredo Sordelli … sordellii. Some initially considered it to be a pathogenic form of C. …