Molecular and epigenetic features of melanomas and tumor immune microenvironment linked to durable remission to ipilimumab-based immunotherapy in metastatic …

T Seremet, A Koch, Y Jansen, M Schreuer… - Journal of translational …, 2016 - Springer
… value of this molecular signature cannot be … tumors and tumor immune microenvironment
in relation with clinical outcome in order to identify solid predictive markers for immunotherapy

Enhancing therapeutic approaches for melanoma patients targeting epigenetic modifiers

M Gracia-Hernandez, Z Munoz, A Villagra - Cancers, 2021 - mdpi.com
Epigenetic alterations can also lead to immune evasion and … to treat patients that do not
respond or become resistant to first… molecules in melanoma cells and decreased tumor growth in …

The local immune response in melanoma. In situ analysis of the micro-environmental immune-signature of primary melanoma.

F Bosisio - 2018 - boa.unimib.it
… and to keep the patient on a durable remission or on a stable … , but integrated also with
molecular melanoma-cell centered … tissue section the immune microenvironment associated with …

[HTML][HTML] Molecular characterization of the clinical and tumor immune microenvironment signature of 5-methylcytosine-related regulators in non-small cell lung cancer

T Liu, L Guo, G Liu, X Hu, X Li, J Zhang… - Frontiers in Cell and …, 2021 - frontiersin.org
… For background correction and normalization, the Robust … of immunotherapy outcomes.
However, the survival analysis … Epigenetic alterations are associated extensively with the …

Long-term complete remission with Ipilimumab in metastatic castrate-resistant prostate cancer: case report of two patients

L Cabel, E Loir, G Gravis, P Lavaud, C Massard… - … for immunotherapy of …, 2017 - Springer
… for the treatment of patients with melanoma after an … immunotherapy-sensitive cancer
subtypes [27, 28]. Staining was negative in one of our patients and it could not be performed due

Soluble CTLA-4 as a favorable predictive biomarker in metastatic melanoma patients treated with ipilimumab: an Italian melanoma intergroup study

…, P Queirolo, Italian Melanoma Intergroup (IMI) - … , Immunotherapy, 2019 - Springer
… among patients in irCR/irPR (immune-related complete/partial … However, the benefit in terms
of long-lasting disease control … (ALC) [18], and epigenetic features of melanoma and tumor

Phenotypic characterization of tumor CTLA-4 expression in melanoma tissues and its possible role in clinical response to Ipilimumab

MP Pistillo, R Carosio, F Grillo, V Fontana… - Clinical …, 2020 - Elsevier
Molecular and epigenetic features of melanomas and tumor immune microenvironment
linked to durable remission to ipilimumab-based immunotherapy in metastatic patients

[HTML][HTML] Biomarkers for response of melanoma patients to immune checkpoint inhibitors: a systematic review

CAC Jessurun, JAM Vos, J Limpens… - Frontiers in oncology, 2017 - frontiersin.org
… of advanced melanoma patients have durable responses to … mostly due to an unclear
description of follow-up data of patients … should display an active immune microenvironment. In 12 …

Genetic and epigenetic biomarkers of immune checkpoint blockade response

Q Xiao, A Nobre, P Piñeiro… - Journal of clinical …, 2020 - mdpi.com
… of JAK family members render melanoma resistant to IFN-γ … be related to progressive disease
in melanoma patients. … of the anti-tumor immune reactivation could be related to the post-…

[HTML][HTML] Molecular immunotherapy: promising approach to treat metastatic colorectal cancer by targeting resistant cancer cells or cancer stem cells

S Forster, R Radpour - Frontiers in oncology, 2020 - frontiersin.org
… response, they are associated with virtually no activity in patients with pMMR/… remission
rates in metastatic CRC (60). Recently, modern molecular analysis has shown that melanoma