… frequency of PGRN mutations in all dementia patients. Our findings show that mutations in
PGRN are a major cause of FTLD-U, expand the range of PGRN mutations identified to date …

… had ubiquitin-positive inclusions in the frontotemporal neocortex, … suggested that some PGRN
mutation carriers may have motor … for familial frontotemporal lobar degeneration with motor …

… inclusions and those with ubiquitin-positive inclusions. Two … that mutations in the progranulin
gene (PGRN) are associated with frontotemporal lobar degeneration with ubiquitin-positive …

… Mutations in the gene that encodes progranulin (GRN) on chromosome 17q21–22 have
been identified in patients with hereditary FTD who have tau-negative, ubiquitin-positive …

… dominant frontotemporal dementia with ubiquitin-positive, tau-… null mutations in the
progranulin gene (PGRN). Hereditary dysphasic disinhibition dementia (HDDD) is a frontotemporal …

… family, consistent with each mutation resulting in a loss of function of the mutant allele.
This study suggests that the presence of ubiquitin-positive lentiform intranuclear inclusions in …

… The most common pathology in frontotemporal dementia (FTD) is tau-… , we identified mutations
in the progranulin (PGRN) gene as the cause of … FTLD with ubiquitin-positive inclusions …

… to distinguish different frontotemporal lobar degenerations (FTLDs), and progranulin (PRGN)
mutation analysis. … In conclusion, HDDD1 is an FTLD-U caused by a PGRN mutation and is …

… C: Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked
to chromosome 17q21. Nature 2006;442:920–924. 18 Skibinski G, Parkinson NJ, Brown JM, …

… mutations in progranulin (PGRN). Phenotypes of PGRN and MAPT … mutations causing
FTLD and investigate the associated clinical characteristics in comparison to MAPT mutation …