… strategies such as magnetic resonance imaging that allow monitoring of fibrosis in vivo, …
.2, 36 In this study we tested antibody-mediated myostatin blockade on Sgcg −/− mice, a model …

… seen from analysis of three to four mice per genotype per marker, although data from only
two mice in each group are shown (mouse 1 and mouse 2). L7 is a housekeeping control …

… mouse was anesthetized with 2% isoflurane and function of … muscle pathology in LGMD
mouse models. In contrast to TGF-β, … test regime, since myostatin is profoundly involved in whole …

… We hypothesized that the attenuation of myostatin would … there was no improvement of
muscle function or histopathology … 2) was diluted in blocking wash buffer and incubated in the …

… In milder types of limb girdle muscular dystrophies with later … Secondary pathology of muscular
dystrophy and therapeutic … The DBA/2-mdx model is currently being further characterized …

… mice, limb-girdle muscular dystrophy (LGMD) 1C model mice … , elimination of myostatin did
not recover the pathology in … Only 2 weeks are required for the soluble form of ACVR2B to …

… , and the regenerative capacity of primary muscle cells. We found that in murine models of
LGMD 2B and 2C, daily prednisone dosing reduced muscle damage and fibroinflammatory …

… have historically been classified into 2 main categories based on the … In this study, they
showed that myostatin inhibition by … of muscle pathology in mouse models of Duchenne muscular …

… in normal and dystrophic mouse models for >2 years, even … mdx animals reversed muscle
pathology and improved strength, … in the mdx mouse model of Duchenne muscular dystrophy (…

… muscle known as limb girdle muscular dystrophy 2B. To achieve gene delivery of plasmids
encoding dysferlin to hind limb muscles of … Figure 2C indicates that the average luciferase …