… fusion and two novel isoforms. Knockdown by small interfering RNA in either cell line resulted
in decreased proliferation, increased … demonstrate that the novel BRD4–NUT fusion in PER…

… patient-derived tumor cells expressed a novel in-frame BRD4-NUT fusion transcript with …
Novel BRD4-NUT fusion isoforms increase the pathogenic complexity in NUT midline carcinoma…

… in-frame fusion gene encodes a BRD4-NUT fusion protein … identification of several novel
NUTM1-fusion partners, including … outcomes in NUT midline carcinoma of the head and neck. …

… involving NUT, usually BRD4-NUT fusion genes and, less commonly, … The short isoform is
nearly entirely included in BRD4-NUT, … BRD4-NUT fusion oncogene: a novel mechanism in …

… At the same time, combination approaches and novel targeted … C), only isoform C, ubiquitously
expressed, is involved in the … of the oncogenic chromatin complex in BRD4–NUT cells. …

… in BRD4–NUT-expressing NMCs. These findings identify NSD3 as a … complex with similar
function to BRD4–NUT. Indeed, siRNA knockdown of BRD4, both long and short isoforms, …

… -cut to bypass the complex process of accumulating genetic … as naturally occurring long
and short isoforms. The t(15;19) … Our study identifies SOX2 as a novel target for BRD4-NUT as …

… pathogenetic role in this extremely lethal form of carcinoma. … likely to be complex in the
t(15;19) carcinoma. One scenario … of BRD4 long isoform; (b) increased avidity of BRD4-NUT in …

… result in the development of possible novel targeted therapies. … involving the NUT midline
carcinoma family member 1 (… its fusion with NUTM1 results in a powerful oncogenic complex. …

… Recently, MDs were found to form a novel nuclear sub-… NUT carcinoma (NC, aka NUT midline
carcinoma) is a rare … interactors of BRD4-NUT compared with those of the short isoform of …