Novel regioselective hydroxyl-alkylation of 4, 5-diphenylimidazole-2-thione and a competitive intramolecular ring closure of the S-hydroxyalkyl-imidazoles to imidazo  …

ESH El Ashry, N Rashed, LF Awad… - … , and Nucleic Acids, 2007 - Taylor & Francis
… This work describes the regioselective alkylation of 4,5-diphenylimidazole-2-thione (1) by
reaction with one and two equivalents of different hydroxyl-alkylating agents including …

Introducing of acyclonucleoside analogues tethered 1, 2, 4-triazole as anticancer agents with dual epidermal growth factor receptor kinase and microtubule inhibitors

MR Aouad, HM Al-Mohammadi, FF Al-Blewi… - Bioorganic …, 2020 - Elsevier
… and convenient regioselective synthesis of a novel series of S… Base assisted thermal
intramolecular dehydrative cyclization of … Under the conditions of sodium ethoxide as basic …

Synthesis and Antiviral Evaluation of Some 5‐N‐Arylaminomethyl‐2‐glycosylsulphanyl‐1,3,4‐oxadiazoles and Their Analogs against Hepatitis A and Herpes …

WA El‐Sayed, NM Fathi, WA Gad… - Journal of …, 2008 - Taylor & Francis
… The 1,3,4‐oxadiazole ring has been found in the skeleton of fungicidal and bactericidal,
analgetic, antipyretic, antiphlogistic, anticompulsive, and paralytic hypnotic and sedative agents,…

Synthesis and anticancer activity of new [(Indolyl) pyrazolyl]-1, 3, 4-oxadiazole thioglycosides and acyclic nucleoside analogs

WA El-Sayed, WI El-Sofany, HAR Hussein… - … and Nucleic Acids, 2017 - Taylor & Francis
… in inspiring novelfunction and bearing phenyl, ring without substituents, exhibited higher
activity with respect to the three cancer cell lines. Moreover, the 1,3,4-oxadiazolyl ring system …

Synthesis and in vitro antitumor activity of new substituted thiopyrimidine acyclic nucleosides and their thioglycoside analogs

WA El-Sayed, AE Rashad, SM Awad… - … , Nucleotides and Nucleic …, 2009 - Taylor & Francis
… The role of the prepared compounds as free radical regulators and the therapeutic … The
reaction mixture was stirred at 60C for 4 hours then cooled and the precipitated solid was filtered, …

Synthesis and anti-hepatitis B activity of new substituted uracil and thiouracil glycosides

MT Abdel-Aal - Archives of pharmacal research, 2010 - Springer
Novel Regioselective Hydroxyl-Alkylation of 4,5-Diphenylimidazole… 2-Thione and A
Competitive Intramolecular Ring Closure of the SHydroxyalkyl-Imidazoles to Imidazo[2,1-b]Thiazines