… combinations for overcoming drug resistance. … discusses novel strategies and challenges
in early drug development for advanced prostate cancer, with a focus on the development and …

… and, therefore, novel strategies for disrupting AR signaling … inhibitors that could test our
hypothesis had been developed; … <3% of prostate cancers (47), and, therefore, drug discovery …

… advanced prostate cancer, as have CTC counts in metastatic … of drug development, so
that questions and hypotheses … more likely to benefit from novel therapies. An example could …

… Here we focus on novel models developed in recent years; details for established models
are covered elsewhere (Shen and Abate-Shen 2010; Hensley and Kyprianou 2012; Ittmann et …

… to assess the biology, the grade of development of the tumor and … The hypothesis of the
mutational field may help not only to … -positive prostate cancer could benefit from novel inhibitors …

… novel therapeutic approaches for this disease. The aim of this review is to summarize the
current literature on the biology and treatment of castrate-resistant prostate cancer. … hypothesis, …

… working hypotheses can be generated, such as modulation of a particular biological pathway
that … CADD campaign, we will discuss our recent discovery of novel AR DBD inhibitors, (42) …

… -resistant prostate cancer) was in place at the outset of drug … to the underlying biology of
human cancer are therefore … novel therapeutics applicable to a wide range of cancer types…

… of drug discovery, this review focuses on non-cancer drugs that … novel small molecules or
drug compounds through initiating with a hypothesis or generating new hypotheses about how …

… may help evaluate the ability of therapies to prolong survival and assist in drug development.
… While in the present study we have used prostate cancer as a model, the biology described …