… We hypothesized that an increasing neural respiratory drive (NRD) is associated with the
severity of sleep-disordered breathing at altitude. Methods: Mountaineers were studied at sea …

… by waking neural drive [8] and resultant apnea when this drive is lost during sleep. The PCO2
… Small observational studies revealed that trekkers in Nepal (5050m above sea level) with …

… being a part of a large mass of nervous tissue with relatively low perfusion, unlike carotid
body. … breathing with apnea according to our observation presented in fig. 10. A decreased …

… with increasing altitude may explain the observation of worsening sleep with increasing …
The cost to the central nervous system of climbing to extremely high altitude. N Engl J Med …

… The severity of PB is determined to be aggravated by an increasing neural respiratory drive
(NRD)… from observational studies. At a 3500 m hotel, 46% of 100 Iranian ski tourists reported …

… to moderate/high altitudes is the central sleep apnea syndrome,[6] but exposure to … from
observational and intervention studies regarding the effects of altitude on breathing during sleep …

… instability and thus central sleep apnea. Thus the second … autoregulation would be lowered
during sleep at high altitude. … This observation offers rationale for further studies on the …

… increase in sympathetic nervous system activity[… drive the P a CO 2 below the apnea threshold
which resides within only 1 to 2 mm Hg of the eupneic PCO 2 during sleep at high altitude. …

… This suggestion is based on the observation that hypoventilation is a physiological feature
… during sleep in polycythemia of high altitude: improvement with respiratory stimulation. …

… restore neural or ventilatory responsiveness to control levels. … The control of breathing and
brain O 2 delivery during sleep … exhibited irregular breathing and desaturation during sleep. …