… To our knowledge, these are the first published results in patients on high-dose morphine
rotated to transdermal buprenorphine. This study has limitations, including the lack of a …

… effects, risky opioid regimens (eg, high dose and/or sedative coprescriptions), and aberrant
… (eg, morphine and oxycodone) for pain on most of the past 90 days, and were initiated on …

… ratio is 1:115, giving a 24-hour morphine equivalent … of morphine for many opioid-dependent
chronic pain patients. We present a novel method of high-dose sublingual buprenorphine …

… and 70 μg/h doses (Transtec™; Napp Pharmaceuticals Ltd, … buprenorphine has a better
therapeutic index than morphine … strategy when rotating off high-dose opioids to buprenorphine (…

… to pain management for some patients with chronic pain, IR opioids may be used to supplement
ER/LA-opioid … opioid analgesics, including codeine, morphine, tramadol, fentanyl, and …

… and myoclonus seen after high-dose morphine administration. … to AEs, alternative opioids
such as buprenorphine TD patch … The common dosage was TD buprenorphine (Transtec ® 35, …

… , patients on high-dose morphine who switched to TD BUP prevalently for insufficient pain
relief substantially improved their clinical conditions in about 95% of cases, with most patients …

… Analgesic responses from buprenorphine at 0.3 to 0.4 mg intramuscular doses and 0.4 mg …
dose of morphine in postoperative pain patients. Relative to other opioids, buprenorphine has …

… opioid to transdermal buprenorphine, or in combining the buprenorphine patch with intravenous
morphine … non-European country in which Transtec ® became available was Chile in …

… to consider buprenorphine first-line opioid for chronic pain, … Oxycodone and morphine
reduce acute pain when patients … in patients on a high-dose buprenorphine maintenance …