Pathomechanisms of posttraumatic osteoarthritis: chondrocyte behavior and fate in a precarious environment

J Riegger, RE Brenner - International journal of molecular sciences, 2020 - mdpi.com
… development of so-called posttraumatic osteoarthritis (PTOA). … pathomechanisms of PTOA
and in particular the behavior and fate of the surviving chondrocytes, comprising chondrocyte

[图书][B] Modeling the Post-injury Joint Environment for the Investigation of Post-traumatic Osteoarthritis

S Ayala - 2022 - search.proquest.com
… used to spatially map chondrocyte behavior in Gnee and anGle cartilage … Pathomechanisms
of posttraumatic osteoarthritis: Chondrocyte behavior and fate in a precarious environment

Microenvironment in subchondral bone: predominant regulator for the treatment of osteoarthritis

W Hu, Y Chen, C Dou, S Dong - Annals of the rheumatic diseases, 2021 - ard.bmj.com
Osteoarthritis (OA) is a degenerative joint disease in the elderly. Although OA has been
considered as primarily a disease of the articular cartilage, the participation of subchondral bone …

[图书][B] … the Structural and Functional Consequences of Traumatic Joint Injury and Their Relation to NF-κB in a Non-invasive Model of Post-traumatic Osteoarthritis

IM Berke - 2020 - search.proquest.com
behavior and cartilage pathology in a non-invasive loading model of post-traumatic osteoarthritis
… inhibitor in a non-invasive loading model of post-traumatic osteoarthritis (Chapter 3) ......…

Continuous detrimental activity of intra-articular fibrous scar tissue in correlation with posttraumatic ankle osteoarthritis

NT Tran, SH Jeon, YJ Moon, KB Lee - Scientific Reports, 2023 - nature.com
… Inadequate knowledge exists regarding the risk factors and pathomechanisms that …
may reduce posttraumatic osteoarthritis development, consistent with our findings 33,34 . …

[HTML][HTML] Simvastatin and fluvastatin attenuate trauma-induced cell death and catabolism in human cartilage

J Riegger, S Maurer, S Pulasani… - … in Bioengineering and …, 2022 - frontiersin.org
… are known to induce pathomechanisms that might lead to posttraumatic osteoarthritis (PTOA). …
confirmed during chondrogenic redifferentiation of high passage chondrocytes. However, …

A VCP modulator, KUS121, as a promising therapeutic agent for post-traumatic osteoarthritis

M Saito, K Nishitani, HO Ikeda, S Yoshida, S Iwai… - Scientific Reports, 2020 - nature.com
… in chondrocytes. The aim of this study was to show KUS121 (1) inhibits chondrocyte death
… , Japan) were acclimatised to the new environment for a week before interventions. The rats …

Functional loss of terminal complement complex protects rabbits from injury-induced osteoarthritis on structural and cellular level

J Riegger, H Joos, V Möhler, F Leucht, K Rading… - Biomolecules, 2023 - mdpi.com
… driver in the pathogenesis of posttraumatic osteoarthritis (PTOA). … to characterize the behavior
and fate of chondrocytes after … Our previous studies on TCC-mediated pathomechanisms

Involvement of complement peptides C3a and C5a in osteoarthritis pathology

N Schäfer, S Grässel - Peptides, 2022 - Elsevier
… Prevention of TCC-mediated pathomechanisms might maintain cartilage … Pathomechanisms
of posttraumatic osteoarthritis: chondrocyte behavior and fate in a precarious environment

The hexosamine biosynthetic pathway as a therapeutic target after cartilage trauma: modification of chondrocyte survival and metabolism by glucosamine derivatives …

J Riegger, J Baumert, F Zaucke… - International journal of …, 2021 - mdpi.com
… The surviving chondrocytes secrete excessive amounts of catabolic enzymes, such as … , in
particular due to the complex pathomechanisms involved. Most therapeutic approaches, such …