… Here we show that female mice deficient for PAD6 do … cytoskeletal sheet formation in the
early embryo due to lack of citrullination indicates an essential role for PAD6 in female fertility…

… in cytoskeletal reorganization in the egg and early embryo. … organelles required for early
development. In the fully grown … Ovaries from fertile ICR female mice were fixed in neutral …

… have shown that PAD6 is essential for female fertility with the … that PAD6 localizes to a
poorly characterized cytoskeletal … that PAD6 appears to play a critical role in oocyte maturation, …

… oocyte and early embryo, PADI6 is crucial for early embryonic development and female fertility
… cell lines, potentially affecting cellular cytoskeletal dynamics and cell migration. Together …

… KO mice are infertile, while males are fertile [93]. A similar … complex in the oocyte cytoplasm,
which is required for early … In non-reproductive models, the citrullination of cytoskeletal …

… Our findings indicate that Nobox is a critical regulator that orchestrates oocyte-specific …
Pad6-deficient females are infertile due to failure of oocyte cytoskeletal sheet formation during …

… proteins, peptidylarginine deiminase 6, localizes to and is required for the … Peptidylarginine
deiminase (PAD) 6 is essential for oocyte cytoskeletal sheet formation and female fertility. …

… mutations in the peptidylarginine deiminase type VI (PADI6) … in mammalian oocytes and
early embryos, essential for … cofilin controlled the formation of the actin cytoskeleton which …

… that peptidylarginine deiminase 6 (PADI6), a highly abundant … , roles in signaling to the
oocyte cytoskeleton. Lastly, the recent … Cytoskeletal sheets of mammalian eggs and embryos: a …

… interaction of YWHA with peptidylarginine deiminase type VI (… PADI6 is associated with oocyte
cytoplasmic sheets, and … , the developing germ cell undergoes chromatin and cytoskeletal …