… pharmacodynamics and safety of midazolam after intravenous infusion or oral administration
in preterm infants… of response to midazolam in a substantial portion of preterm infants is due …

… of midazolam after intravenous administration [3]. Following … This ‘impaired’ midazolam
elimination in preterm infants mirrors … Moreover, in preterm infants, decreased midazolam …

… This article reviews the clinical pharmacology, pharmacodynamics and pharmacokinetics of
… IV loading doses should not be used in neonates and preterm infants. Instead, the infusion …

… in a limited percentage of infants following intravenous infusion of midazolam. In conclusion,
… Cl of midazolam is lower in preterm infants than in older children and adults [2]. The percent …

… as a rapid intravenous bolus dose every 4-6 h to 60 very premature neonates with a mean
(… ventilated, preterm infants with birth weights less than 1,500 g requiring midazolam for …

… pharmacokinetics and pharmacodynamics of midazolam in … of age, the pharmacodynamics
of intravenously administered … brain may be increased in preterm infants because the blood-…

… Thummel and colleagues24 in a cross-over study of both intravenous and oral midazolam
PK in 20 healthy adults, showed that both liver and gut contributed equally to the first-pass …

… infants aged younger than 1 yr, information about pharmacokinetics and pharmacodynamics
of intravenous … According to the literature, the optimal dose of midazolam may vary …

… Clearance and midazolam dose in neonates was also predicted … of midazolam clearance in
preterm neonates and term … 0.1 mg/kg midazolam given by intravenous (IV) infusion over 30 …

… A dose of 0.1 mg/kg midazolam was simulated as oral administration or as a 30-minute
intravenous infusion in 37 preterm neonates with the same patient characteristics as the …