… results in a less severe growth defect than depletion of … critical mitochondrial processes.
In contrast to bacteria and yeast, CL synthesis is essential for growth of Trypanosoma brucei in …

… involving CDP-activated intermediates is essential in T. … are localized to mitochondria-associated
membranes, ie special … to phosphatidylglycerophosphate (PGP) by PGP synthase, the …

… To determine if TbSpl expression is essential for survival of T. brucei, growth of TbSpl KO …
, a sub-compartment of ER and mitochondria commonly known as mitochondria associated …

… We demonstrate that expression of TbHMIT is essential for normal growth of T. … A similar
time-dependent linear increase in cell-associated radioactivity was also observed for RNAi …

… are localized in mitochondria-associated membranes, differ in … that sphingolipid synthesis
is essential for growth of T. … -3-phosphate to form phosphatidylglycerophosphate (PGP), which …

… , the synthesis of cardiolipin is essential for growth of … CL associates with several respiratory
chain complexes and … is used by phosphatidylglycerophosphate (PGP) synthase to produce …

… cells, CL synthesis is essential in Trypanosoma brucei. By … in CL synthesis:
phosphatidylglycerophosphate synthase (35)… this tight association with membrane proteins, …

… should rescue the defect in PE synthesis and restore growth of T. …
Phosphatidylglycerophosphate synthase associates with a mitochondrial inner membrane complex …

… brucei, and was shown to be essential in both life cycle stages. … 1.1 Distribution of Human
African Trypanosomiasis species … 26 1.3 Cartoon of Trypanosoma brucei showing major …

… glycerophospholipid that associates with mitochondrial … acid, CDP-diacylglycerol,
phosphatidylglycerophosphate and … 0.05) in several key metabolites associated with energy …