Preliminary Evaluation of the Interactions of Panax ginseng and Salvia miltiorrhiza Bunge with 5-Fluorouracil on Pharmacokinetics in Rats and Pharmacodynamics …

C Gu, J Qiao, M Zhu, J Du, W Shang, W Yin… - The American Journal …, 2013 - World Scientific
… It is therefore important to study the potential consequences of the interactions … from Panax
ginseng (PGS) and Salvia miltiorrhiza Bunge (SMB) on the pharmacokinetics of 5-fluorouracil (…

… evaluation of the interactions of Panax ginseng and Salvia miltiorrhiza Bunge with 5-fluorouracil on pharmacokinetics in rats and pharmacodynamics in human cells.

GCX Gu ChenXin, QJP Qiao JinPing, ZML Zhu MeiLin… - 2013 - cabidigitallibrary.org
… It is therefore important to study the potential consequences of the interactions … from Panax
ginseng (PGS) and Salvia miltiorrhiza Bunge (SMB) on the pharmacokinetics of 5-fluorouracil (…

[HTML][HTML] A review of the pharmacodynamic effect of chemo-herbal drug combinations therapy for cancer treatment

A Okem, C Henstra, M Lambert, R Hayeshi - Medicine in Drug Discovery, 2023 - Elsevier
Salvia miltiorrhiza Bunge Oxaliplatin glioblastoma Relieve … growth of tumours and prolong
the survival time of mice. H22 … The Ginseng species, Panax ginseng and 5-fluorouracil both …

A comprehensive review of recent studies on herb-drug interaction: a focus on pharmacodynamic interaction

JG Choi, SM Eom, J Kim, SH Kim, E Huh… - The Journal of …, 2016 - liebertpub.com
… by examining pharmacodynamic (PD) and pharmacokinetic (… as using experimental animals,
such as mice, rats, or dogs. In … of 5-fluorouracil in HCT116 human colon cancer cell line 47 …

Impact of Drug Metabolism/Pharmacokinetics and their Relevance Upon Salviabased Drug Discovery

DC Hao, PG Xiao - Current Drug Metabolism, 2017 - ingentaconnect.com
… of various Salvia species, especially Salvia miltiorrhiza, are … impact the PK/pharmacodynamic
performance of compounds … Salvia miltiorrhiza gradients in rat plasma and brain by LC- …

Herbal interactions with anticancer drugs: mechanistic and clinical considerations

AK Yang, SM He, L Liu, JP Liu… - Current medicinal …, 2010 - ingentaconnect.com
… interindividual variability in their pharmacokinetics and this can … of ginseng also did not affect
the pharmacodynamics of … and in vivo studies in rats at our laboratory demonstrated that St …

[PDF][PDF] Medicine in Drug Discovery

A Okem, C Henstra, M Lambert, R Hayeshi - researchgate.net
… The Ginseng species, Panax ginseng and 5fluorouracil both show an … Preliminary Evaluation
of the Interactions of Panax ginseng and Salvia miltiorrhiza Bunge with 5-Fluorouracil on …

Herbal Medicines as Adjuncts to Cancer Chemotherapy—Part 1: Immunomodulators

E Yarnell, C Zimmerman - Alternative and Complementary …, 2019 - liebertpub.com
Preliminary evaluation of the interactions of Panax ginseng and Salvia miltiorrhiza Bunge
with 5-fluorouracil on pharmacokinetics in rats and pharmacodynamics in human

[HTML][HTML] Protopanaxadiol, an active ginseng metabolite, significantly enhances the effects of fluorouracil on colon cancer

CZ Wang, Z Zhang, JY Wan, CF Zhang, S Anderson… - Nutrients, 2015 - mdpi.com
… active ginseng compounds, such as PPD [11], its interactions … Future pharmacokinetic
studies will be performed, and the … mice inoculated with HCT-116 human colorectal cancer cells

Simultaneous determination of the novel anti-tumor candidate drug MDH-7 and 5-fluorouracil in rat plasma by LC-MS/MS: Application to pharmacokinetic interactions

J Li, Y Chen, P Zhou, Q Fan, Q Wang, X Chen… - … of Chromatography B, 2018 - Elsevier
Preliminary pharmacokinetic studies showed that MDH-7 had a wide range of … interactions
may be mediated by physicochemical properties, pharmacokinetic and pharmacodynamic