Preparation and Functional Analysis of TumorInfiltrating Stroma Cells Using Bone Marrow Chimera Mice

H Ishigaki, Y Yamamoto, H Ishida… - Microbiology and …, 2006 - Wiley Online Library
… In this study, using GFPTg mice and BM chimera mice reconstituted with GFPTg mice, we …
ImC and the others are non-BM derived CD11b-positive and CD11b-negative cells. These …

[PDF][PDF] Preparation and functional analysia of tumor-infiltrating stroma cells using bone marrow chimera mice.

石垣宏仁 - 2006 - shiga-med.repo.nii.ac.jp
… の結果で見られたCDllb+cellは骨髄由来の分画と非骨髄由来 の分画に分類されることが判った.…
骨髄由来のlmC,非骨髄由来のCDllb+cellと CDllb.cellである.このうち非骨髄由来の細胞は,線維芽…

… MMP-9 inhibition breaks the tumor-bone marrow axis responsible for myeloid-derived suppressor cell expansion and macrophage infiltration in tumor stroma

C Melani, S Sangaletti, FM Barazzetta, Z Werb… - Cancer research, 2007 - AACR
… treatment, we used bone marrow chimeras to knock down MMP-… reduced tumor infiltrating
and stromal leukocytes and … In these mice, the radio-resistant stroma within bone marrow

THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer

M Omatsu, Y Nakanishi, K Iwane, N Aoyama… - Nature …, 2023 - nature.com
… This study highlights the critical importance of bone marrow (… MTO-inoculated mice, like that
in human CRC, and its stroma-… mice into WT mice and generated GFP-BM chimeric mice for …

Tumor-infiltrating DCs suppress nucleic acid–mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1

S Chiba, M Baghdadi, H Akiba, H Yoshiyama… - Nature …, 2012 - nature.com
… Among single-cell suspensions prepared from subcutaneous … adjuvant, we generated
mixed–bone marrow chimeras that could be … and CD45 − stromal cells, and natural killer cells and …

Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice

Y Sawanobori, S Ueha, M Kurachi… - Blood, The Journal …, 2008 - ashpublications.org
… site were composed primarily of bone marrow-derived CD11b + … It is thought that tumor-infiltrating
inflammatory cells play an … for various time periods before cell preparation on day 14 of …

Neutrophils responsive to endogenous IFN-β regulate tumor angiogenesis and growth in a mouse tumor model

J Jablonska, S Leschner, K Westphal… - The Journal of …, 2010 - Am Soc Clin Investig
… -cell solutions were prepared, stained, and analyzed using … control mice and reconstituted
them with bone marrow from … , we carried out the analysis of tumor-infiltrating CD11b + Gr1 + …

Macrophage-derived SPARC bridges tumor cell-extracellular matrix interactions toward metastasis

S Sangaletti, E Di Carlo, S Gariboldi, S Miotti… - Cancer research, 2008 - AACR
… SPARC produced by tumor and nearby stroma cells. Host-derived SPARC … Bone marrow
macrophage preparation. … was found in cells that appear as tumor-infiltrating inflammatory cells

Monocyte chemoattractant protein-1/CCL2 produced by stromal cells promotes lung metastasis of 4T1 murine breast cancer cells

T Yoshimura, OMZ Howard, T Ito, M Kuwabara… - PloS one, 2013 - journals.plos.org
… Although the composition of tumor infiltrating leukocytes and the … of 4T1 cells, we generated
bone marrow chimera mice and … Tissue sections were prepared from the center of each tumor…

IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors

SP Kerkar, RS Goldszmid, P Muranski… - The Journal of …, 2011 - Am Soc Clin Investig
… We next created bone marrow chimeras using C57BL/6 WT … the capability of polarizing
tumor-infiltrating neutrophils to an … To determine whether this pretreatment preparation in some …