Rapamycin can Inhibit the Development of Chlamydia pneumoniae, which Might Partly Contribute to the Prevention of In-stent Restenosis

Y Yan, S Silvennoinen-Kassinen, M Leinonen… - … drugs and therapy, 2010 - Springer
pneumoniae in the present study. Therefore our findings suggest that the beneficial effects
of rapamycin in the prevention of in-stent restenosis might partly be explained by its inhibition

The antichlamydial effects of drugs used in cardiovascular diseases

Y Yan - 2009 - oulurepo.oulu.fi
… Chronic Chlamydia pneumoniae infections have been associated … COX inhibitors and
rapamycin can inhibit the infectivity of C. … of allograft and in-stent restenosis may be partly due to its …

Immunologic mechanisms and treatment of acute coronary syndromes

LIU Ying, Y Liao, X Cheng - Chinese medical journal, 2006 - journals.lww.com
… , EB virus) and bacteria (Chlamydia pneumoniae, HP) are … (iNOS), which at least in part
contributes to the depression of … administered rapamycin inhibits in-stent neointimal growth in …

Recent advances in technologies for developing drugs against Chlamydia pneumoniae

L Hanski, PM Vuorela - Expert opinion on drug discovery, 2014 - Taylor & Francis
… Conventional antibiotics mostly target the multiplication phase, which may not, however, …
used for restenosis prevention in patients with coronary artery disease in the form of rapamycin-…

Association between bacterial infection and peripheral vascular disease: a review

J Budzyński, J Wiśniewska… - … Journal of Angiology, 2016 - thieme-connect.com
… pylori, and Chlamydia pneumoniae. Infectious agents … restenosis,[111] [134] and, because
rapamycin can inhibit its … in preventing infection-induced in-stent restenosis might be the use …

Coronary restenotic reduction of drug-eluting stenting may be due to its anti-inflammatory effects

JJ Li, J Li, JL Nan, Z Li, X Zhen, CW Mu, J Dai… - Medical hypotheses, 2007 - Elsevier
may play an important role in determining in-stent restenosis … including cytomegalovirus,
Chlamydia pneumoniae, Epstein-… inhibiting the expression of such genes, rapamycin may lead

Altered trafficking of CD8+ memory T cells after implantation of rapamycin-eluting stents in patients with coronary artery disease

G Sardella, D Accapezzato, A Di Roma, V Francavilla… - Immunology letters, 2005 - Elsevier
could partially explain the reduction of coronary in-stent … have been developed intended to
prevent in-stent restenosis. … from a pathogen such as Chlamydia pneumoniae [32] or an auto-…

Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence

CA Hinojosa, V Mgbemena, S Van Roekel… - Experimental …, 2012 - Elsevier
might benefit the most from therapeutic rapamycin, the elderly, are also at increased risk for
bacterial pneumonia due in part … contrast, rapamycin inhibited the development of Chlamydia

Inhibition of neointima formation by a novel drug-eluting stent system that allows for dose-adjustable, multiple, and on-site stent coating

R Wessely, J Hausleiter, C Michaelis… - … , and vascular biology, 2005 - Am Heart Assoc
… , we developed a stent-coating platform that can be operated … that these stents may efficiently
inhibit in-stent restenosis in … an increase in rapamycin dosage on DES may lead to a more …

Overview of therapies for prevention of restenosis after coronary interventions

SM Garas, P Huber, NA Scott - Pharmacology & Therapeutics, 2001 - Elsevier
… However, in-stent restenosis presents a new and an even … frequently implicated is Chlamydia
pneumoniae, a common … Rapamycin is a cytostatic drug that induces late G1 cell-cycle …