[HTML][HTML] Rosmarinic acid attenuates hepatic fibrogenesis via suppression of hepatic stellate cell activation/proliferation and induction of apoptosis

NM El-Lakkany, WH El-Maadawy, SHS El-Din… - Asian Pacific journal of …, 2017 - Elsevier
… RA impeded the progression of liver fibrosis through inhibition of HSCs activation/proliferation
and induction of apoptosis with preservation of hepatic architecture. …

[PDF][PDF] Rosmarinic acid attenuates hepatic fibrogenesis via suppression of hepatic stellate cell activation/proliferation and induction of apoptosis

SM Ezzat, MM Safar, S Saleh - Asian Pacific Journal of Tropical …, 2017 - academia.edu
… role of rosmarinic acid (RA), a natural polyphenolic compound, on HSCs activation/proliferation
and apoptosis in vitro and … Rosmarinic acid inhibits proliferation and induces apoptosis of …

[HTML][HTML] Hepatoprotective effects of rosmarinic acid: Insight into its mechanisms of action

TO Elufioye, S Habtemariam - Biomedicine & Pharmacotherapy, 2019 - Elsevier
… It inhibited CCl 4 -induced apoptosis as well as enhanced … β1-induced stellate cell mitogenic
and fibrogenic activation by … suppression of HSC activation/proliferation and induction of …

[PDF][PDF] Rosmarinic acid-a new hope for liver diseases like cirrhosis, hepatocellular carcinoma-needs translation to humans

KK Kaur, GN Allahbadia, M Singh - EC Endocrinology and Metabolic …, 2019 - ecronicon.net
… TNFα induced apoptosis, involves the activation of the … RA also attenuated I/R induced
inflammatory response in liver, it … inhibition by targeting matrix producing hepatic stellate cells […

SIRT1/NFκB pathway mediates anti-inflammatory and anti-apoptotic effects of rosmarinic acid on in a mouse model of nonalcoholic steatohepatitis (NASH)

T Komeili-Movahhed, M Bassirian… - Journal of Receptors …, 2022 - Taylor & Francis
Rosmarinic acid attenuated apoptosis pathway related … fact, hepatic lipid accumulation
triggers hepatic stellate cells, … that RA suppressed high glucose-induced apoptosis via decrease …

[HTML][HTML] Therapeutic Potential and Mechanisms of Rosmarinic Acid and the Extracts of Lamiaceae Plants for the Treatment of Fibrosis of Various Organs

YC Boo - Antioxidants, 2024 - mdpi.com
… , and Perilla frutescens, have been shown to attenuate fibrosis of the liver, kidneys, heart,
lungs, … to inhibit cell proliferation and induce apoptosis in the activated hepatic stellate cell line (…

[HTML][HTML] A comprehensive review of natural products against liver fibrosis: flavonoids, quinones, lignans, phenols, and acids

X Pan, X Ma, Y Jiang, J Wen, L Yang, D Chen… - Evidence-based …, 2020 - hindawi.com
… A induces apoptosis in activated hepatic stellate cells through ERK1/2 … Rosmarinic
acid attenuates hepatic fibrogenesis via suppression of hepatic stellate cell activation/proliferation

α-Lipoic acid modulates liver fibrosis: a cross talk between TGF-β1, autophagy, and apoptosis

WH El-Maadawy, OA Hammam… - Human & …, 2020 - journals.sagepub.com
… and apoptosis are important players in the progression of hepatic fibrosis via activation of
hepatic stellate cells (… Our results signify that ALA treatment attenuated liver fibrosis partly by …

Salvianolic acid B suppresses hepatic fibrosis by inhibiting ceramide glucosyltransferase in hepatic stellate cells

Z Li, L Jiang, J Ni, Y Xu, F Liu, W Liu, S Wang… - Acta Pharmacologica …, 2023 - nature.com
… in the pathogenesis of hepatic fibrosis. We first found that UGCG was over-expressed in
fibrotic livers and activated hepatic stellate cells (HSCs). In human HSC-LX2 cells, inhibition of …

[HTML][HTML] Baicalin inhibits PDGF-BB-induced hepatic stellate cell proliferation, apoptosis, invasion, migration and activation via the miR-3595/ACSL4 axis

X Wu, F Zhi, W Lun, Q Deng… - … Journal of Molecular …, 2018 - spandidos-publications.com
… of hepatic fibrosis currently focuses on hepatic stellate cell (… activation (8) and induces
apoptosis, senescence or quiescence … the forced expression of ACSL4 attenuated the anti-fibrotic …