Rottlerin potentiates camptothecin-induced cytotoxicity in human hormone refractory prostate cancers through increased formation and stabilization of topoisomerase I …
JL Hsu, YF Ho, TK Li, CS Chen, LC Hsu… - Biochemical …, 2012 - Elsevier
… , through PKCδ-independent pathways [5], … PKCδ-independent pathway to rottlerin action
in this study. However, the single use of rottlerin did not show promising efficacy against cancer …
in this study. However, the single use of rottlerin did not show promising efficacy against cancer …
[HTML][HTML] Co-administration of tyrosine kinase inhibitors with rottlerin in metastatic prostate cancer cells
WA Cieslikowski, T Haber, S Krajnak, K Anic… - EXCLI …, 2021 - ncbi.nlm.nih.gov
… Although prostate cancer is susceptible to hormonal … inhibition of TKI pathways and
administration of rottlerin have additive … Rottlerin was shown to potentiate camptothecin-induced …
administration of rottlerin have additive … Rottlerin was shown to potentiate camptothecin-induced …
[HTML][HTML] Tumor suppressive role of rottlerin in cancer therapy
J Ma, Y Hou, J Xia, X Zhu, ZP Wang - American Journal of …, 2018 - ncbi.nlm.nih.gov
… stabilization of TOP1cc (topoisomerase I-DNA cleavage … against late apoptosis through
PKCδ-independent, but dependent … Rottlerin has been reported to potentiate the antineoplastic …
PKCδ-independent, but dependent … Rottlerin has been reported to potentiate the antineoplastic …
Camptothecin resistance in cancer: insights into the molecular mechanisms of a DNA-damaging drug
GL Beretta, L Gatti, P Perego… - Current medicinal …, 2013 - ingentaconnect.com
… DNA topoisomerases cleave DNA strands during the … to one poison may potentiate cell
sensitivity to structurally distinct … in hormonerefractory prostate cancers exposed to rottlerin Fig. (6)…
sensitivity to structurally distinct … in hormonerefractory prostate cancers exposed to rottlerin Fig. (6)…
Enhanced liver targeting of camptothecin via conjugation with deoxycholic acid
L Xiao, E Yu, H Yue, Q Li - Molecules, 2019 - mdpi.com
… potent anticancer activity through inhibition of topoisomerase I. … the potential liver targeting
and stability of a deoxycholic acid-… acid changed the transport pathway of CPT and the uptake …
and stability of a deoxycholic acid-… acid changed the transport pathway of CPT and the uptake …
Aflatoxin-induced upregulation of protein arginine methyltransferase 5 is mediated by protein kinase C and extracellular signal-regulated kinase
… PKCα/δ inhibitors named Go6976 and rottlerin in the study. The AFB 1 -… Several studies have
reported this complex as a novel and … Our study made an attempt to delineate the pathway …
reported this complex as a novel and … Our study made an attempt to delineate the pathway …
Dimeric camptothecin derived phospholipid assembled liposomes with high drug loading for cancer therapy
… through interference with the activity of topoisomerase I (Topo I) … storage stability of the
di-CPT-GPC liposomal formulation … I-DNA cleavage complexes in a PKCδ-independent pathway …
di-CPT-GPC liposomal formulation … I-DNA cleavage complexes in a PKCδ-independent pathway …
Design and Synthesis of Novel 20-Substituted Hydroxycamptothecin Derivatives
S Wen, D Quan, Y Zhou, H Jia, P Yu, H Sun… - Proceedings of the 2012 …, 2014 - Springer
… a ternary complex with topoisomerase I and DNA, and the stabilization of these complex …
The coupling reaction was the key step in the entire route. In this step, anhydrous and anaerobic …
The coupling reaction was the key step in the entire route. In this step, anhydrous and anaerobic …