Search for new tools to combat Gram-negative resistant bacteria among amine derivatives of 5-arylidenehydantoin

J Handzlik, E Szymańska, S Alibert, J Chevalier… - Bioorganic & medicinal …, 2013 - Elsevier
… contributes to the search of new tools to combat multidrug resistant bacteria among chemical
… From our previous studies, 9 a new series of N3-aminealkyl arylidenehydantoin derivatives

Recent Advances in Multi-Drug Resistance (MDR) Efflux Pump Inhibitors of Gram-Positive Bacteria S. aureus

J Handzlik, A Matys, K Kieć-Kononowicz - Antibiotics, 2013 - mdpi.com
search for new tools to combat multidrug resistance (MDR) … in the search for new EPIs
for Gram-negative pathogens. Results … derivative (13), whereas the 3-amino-N-phenylbenzamide …

Efflux pump inhibitors: a novel approach to combat efflux-mediated drug resistance in bacteria

Y Wang, H Venter, S Ma - Current drug targets, 2016 - ingentaconnect.com
Search for new tools to combat Gram-negative resistant bacteria among amine derivatives
of 5-arylidenehydantoin. Bioorg Med Chem 2013; 21: 135-45. [107] Willoughby JA, Sr, …

Design, synthesis and evaluation of a series of 5-methoxy-2, 3-naphthalimide derivatives as AcrB inhibitors for the reversal of bacterial resistance

C Jin, R Alenazy, Y Wang, R Mowla, Y Qin… - Bioorganic & Medicinal …, 2019 - Elsevier
… pump inhibitors are the 5-arylidenehydantoin derivatives. … inhibitors against antibiotic-resistant
Gram-negative E. coli. … by reaction with the corresponding amines in pyridine to provide …

Multidrug efflux pumps and their role in antibiotic and antiseptic resistance: a pharmacodynamic perspective

S Alibert, J N'gompaza Diarra… - Expert opinion on …, 2017 - Taylor & Francis
… Multidrug resistance (MDR) in Gram-negative bacteria is … and sufficiently relevant about
amino acid residues engaging … the treatment adaptation to combat the bacterium. Computer-…

Three Dimensional Checkerboard Synergy Analysis of Colistin, Meropenem, Tigecycline against Multidrug-Resistant Clinical Klebsiella pneumonia Isolates

C Stein, O Makarewicz, JA Bohnert, Y Pfeifer… - PloS one, 2015 - journals.plos.org
… , OXA-48, VIM or NDM in Gram-negative bacteria [1]. Of these, … set of N3- aminealkyl
arylidenehydantoin derivatives [16] that … of OmpK36 were found at amino acid position 146 in NRZ …

Efflux pump inhibitors for bacterial pathogens: From bench to bedside

A Sharma, VK Gupta, R Pathania - Indian Journal of Medical …, 2019 - journals.lww.com
… is different in Gram-positive and Gram-negative bacteria. … by interacting directly with amino
acid residues in the efflux … Quinoline derivatives such as pyridoquinolones can restore the …

Extending the Potency and Lifespan of Antibiotics: Inhibitors of Gram-Negative Bacterial Efflux Pumps

M Duffey, RP Jumde, RMA da Costa… - ACS Infectious …, 2024 - ACS Publications
… similarity at the DNA and/or amino acid level. Because of their … The University of Sichuan
explored indole derivatives as … stationary phase bacteria because such bacteria stop dividing. …

Antibiotic adjuvants: A promising approach to combat multidrug resistant bacteria

N Sharma, AK Chhillar, S Dahiya… - Current Drug …, 2021 - ingentaconnect.com
… use to combat infections caused by gram-negative bacteria [2]. … that prevent the resistance
development among pathogenic … Indole derivatives like 3-amino-6-carboxyl- indole and 3nitro-…

Recent applications of hydantoin and thiohydantoin in medicinal chemistry

SH Cho, SH Kim, D Shin - European journal of medicinal chemistry, 2019 - Elsevier
… and cyclization of α-amino acid derivatives and isocyanates or … to be emerging therapeutic
targets to overcome some types of … -resistant gram-positive and gram-negative pathogenic …