… agent, there has been no direct comparison between serelaxin and current standard of care
… the antifibrotic effects of serelaxin to that of enalapril in a murine model of cardiac fibrosis. …

… forms of heart disease such as myocardial infarction, cardiac … established cardiac fibrosis in
different experimental models of … the antifibrotic efficacy of serelaxin with that of enalapril. In a …

… system during pregnancy, as well as its anti-fibrotic and anti-… effective than the ACE inhibitor
enalapril in reducing cardiac … experimental design in pre-clinical studies versus clinical trial …

… Heart Association acute heart failure activin receptor-like kinase analysis of variance activator
protein 1 angiotensin-receptor-neprilysin-inhibitor angiotensin 2 adenosine triphosphate …

… due to the lack of adequate experimental models of AHF. It is … to investigate the efficacy
and safety of serelaxin in the treatment … Whether this anti-fibrotic effect of serelaxin is clinically …

… Serelaxin mediates signal transduction in fibroblasts through its cognate receptor RXFP1
and … The antifibrotic efficacy of serelaxin is experimentally equivalent if not better than current …

… -term outcome benefits in acute heart failure. Clinical observations … Despite differences in
experimental design and study subject… of the putative anti-fibrotic effects of serelaxin, including …

… In the same experimental model, serelaxin treatment reduced … anti-fibrotic and anti-hypertrophic
actions of serelaxin have … of enalapril and serelaxin diminished cardiac fibrosis two-fold …

… need to develop novel and effective anti-fibrotic therapies in cardiovascular disease. In this
… relaxin more effectively ameliorated cardiac fibrosis than enalapril in an experimental model …

… Serelaxin is safe and efficacious in protecting organs and … serelaxin alleviates heart failure
by inhibiting cardiac fibrosis … enzyme inhibitor enalapril decreases cardiac fibrosis greatly [24]. …