… The objective of this study was to prepare a 72 h-release formulation of silybin (72 h-SLB) …
and porous silica nanoparticles (PSNs) and to investigate the in vitro/in vivo correlations (…

… Seventy- twohour release formulation of the poorly soluble drug silybin based on porous
silica nanoparticles: in vitro release kinetics and in vitro/in vivo correlations in beagle …

… , et al., Seventy-two-hour release formulation of the poorly soluble drug silybin based on
porous silica nanoparticles: In vitro release kinetics and in vitro/in vivo correlations in beagle …

… After oral administration in beagle dogs of drug entrapped in … Based on the analysis of drug
release profiles in vitro, the … synthesis of monodispersed Porous Silica Nanoparticles (PSNs) …

… have been used to optimize silymarin solubility. Most of the … After oral administration in
beagle dogs of drug entrapped in … the synthesis of monodispersed porous silica NPs (PSNs) by …

… is low due to poor water solubility. This study aimed to … sustained release of silymarin from
porous silica nanoparticles (… Our in vitro release study indicated that, unlike free SBN, which …

… bioavailability 130 of poorly water-soluble drug compounds, … After oral 326 administration
in beagle dogs of SIL entrapped … nanometer- 704 sized pores with sodium carbonate solution. …

… the nano porous silica as well as PEG modified silica matrix … For all the formulations Level A
in vitro-in vivo correlation (IVIVC) … Relationship between fraction dissolved in vitro vs. fraction …

… , and establishment of an in vitro in vivo correlation (IVIVC). … in vivo release from beagle dogs
with in vitro release assessed … et al., “In vitro release and in vitroin vivo correlation for silybin …

… Yu, Seventy-two-hour release formulation of the poorly soluble drug silybin based on
porous silica nanoparticles: in vitro release kinetics and release kinetics and in vitro/in vivo …