… contaminants, preservatives or insulin and manifest as localized or … a severe cutaneous
reaction to insulin which we hypothesize is a manifestation of systemic contact sensitivity to cresol…

… a localized delayed cutaneous reaction to human insulin. … to evaluate sensitivity to commercial
human insulins, meta-cresol, … Severe adverse cutaneous reaction to insulin due to cresol …

… Skin reactions vary from local erythema and swelling at the … , meta-cresol, insulin, and
glycerol were also negative after 20 … Available data indicate that severe adverse reactions could …

… -cresol are accumulated during long-term use of insulin in … , and the skin reaction occurred
on adverse skin, rather than … to poison sensitive person. So we consider that phenol and meta-…

… manufacture insulin have remained the same (eg meta-cresol… changes indicative of a
severe insulin allergy. Glycemic … preservative meta-cresol and a report of cutaneous allergy to …

… I HS reactions to m-cresol have been reported with insulin [20], [24]. To our knowledge, only
one case of m-cresol sensitivity … and chronic, plaque-stage psoriasis who developed acute …

… in the insulin preparation such as protamine, cresol, and … , T-cell mediated skin reactions or
granulomatous hypersensitivity [… In severe cases, a solitary pancreas transplantation was the …

… skin biopsy showing evidence of insulin hypersensitivity. He was desensitized to insulin
according to Heinzerling et al. insulin … , latex, or cresol. Subcutaneous injections compared to …

… and meta-cresol in adequate concentration are added in insulin … Drug intolerance reaction
to insulin therapy caused by … Skin-related complications of insulin therapy: epidemiology and …

… can range from local reactions to severe anaphylaxis. Local … Sensitivity that starts with local
symptoms may be aggravated … A (+) skin reaction may be observed with cresol in saline. 1.5 …