… colorectal tissues in preventing this tumorigenesis, and what are the mechanisms by which
NSAIDs prevent colorectal tumorigenesis… the PGE 2 -GPCR signaling pathway and the APC-β…

… 2-related factor 2, Wnt signaling Core tip: Colorectal carcinogenesis (CRC) imposes a major
… This review addresses the cell death mechanisms and major signal transduction pathways …

… Hyperphosphorylation at the Y705 residue of signal transducer and activator of … ) signaling
pathways that are implicated in tumorigenesis (14). In support, we show that colorectal cancer …

… Resistance to anti-cancer treatments is a critical and … spectrum of patients with advanced
colorectal cancer (CRC) tend … , rendering cancer cells insensitive to the treatment of anti-cancer …

… on the cell signaling cross-talk mechanisms of colorectal cancer (CRC) … These interlinked
signals cross-talk with one another in various … for signal transduction application involving in …

… cross-talk between RNA splicing and Wnt signaling activity is bidirectional, and is associated
with colonic … for proteins with binding or signal transduction/receptor activities and under-…

… in cancer treatment by natural products are MAPK, PI3K/Akt, and NF- κB [4], [5]. Notably, it has
been observed that signal transducer … Breast cancer, colorectal cancer, gastric cancer, and …

… signal transduction during tumorigenesis is still not fully understood. In fact, recent studies
from our laboratory showed that TNF-β signaling … and malignancy of colon cancer cells. …

… TNIK-RAP2A in colorectal cancer cell exosomes. The … signaling pathway components in
metastatic colon cancer cell-derived exosomes contributes to our understanding of the cross-talk …

… role of intestinal microbiota in colorectal cancer. The peculiar … negative risk factors for colorectal
cancer development. Moreover, … of risk and protective factors for colorectal cancer onset. …