… association of p38 signalling in severe asthma, p38 activity has been shown to be
increased in … subjects with severe asthma.24-26 Relative corticosteroid resistance of pro-inflammatory …

… the different manifestations between EA and EB via sputum transcriptomics analysis. …
signaling). In the colored bars, red (or blue) represents increased (or decreased) signaling in EA …

… The p38 MAPK signalling pathway has been identified as … In asthma, it has been implicated
in tissue remodelling, 77, 78 … BLF or induced sputum cell counts and transcriptomic data from …

… Citation22 Indeed, analysis of sputum transcriptomics has … belonging to the p38 MAPK
signalling pathway, associated … Indeed, p38 MAPK is physiologically implicated in the regulation …

… activity, pathogen-associated-pattern-recognition activity, … , immune response and cytokine
signalling processes. The majority of … D in chronic obstructive pulmonary disease, asthma and …

… was increased p38 signaling activity via induced sputum transcriptomics in severe asthma
… Several genes and pathways have been implicated in the treatment of asthma by ART. The …

… In conclusion, we identified BIRC3 mRNA and protein significantly increased in induced
sputum of asthma and were positively correlated with Type 2 airway inflammation. BIRC3 …

… increased ER stress and UPR pathways in asthma and these … These studies implicate that
ER stress/UPR is an important … ER stress signature in the sputum of asthma, we observed that …

… STAT6, resulting in increased mucus production and viscosity … the axis from pathology and
inflammation (p38 MPK, NF-κB, … -kB activity via EGFR-PI3K-Akt/ERK MAPKinase signaling in …

… the first single-cell transcriptomic dataset for human ex vivo … PI3K, MAPK/ERK, and p38
signaling pathways associated with IL-5/… Severe asthma with a sputum eosinophil count of >3% (…