… to promote RBM39 degradation by CRL4 DCAF15 . We find that DCAF15 adopts a structure
… and engages the second RRM domain of RBM39 with an extended, non-conserved surface …

… The following chapter summarizes our structural investigations around the RBM39-ArSulf-DCAF15
interaction. We conduct immunoprecipitation and pull-down experiments with the …

… that thalidomide promotes proteasomal degradation of the Sal-… -EM structure of the
DDB1–DCAF15–DDA1 bound to RBM39 … DCAF15 or RBM39, and formation of the …

… DCAF15 (Figure 4C). Upon docking of dRRM-1 to a published crystal structure of
DDB1ΔB-DDA1-DCAF15-E7820-RBM39, … E3 ligases of interest and facilitate the de novo …

… of DCAF15, and … RBM39 dependence and DCAF15 expression. Here, we demonstrate that
neuroblastoma is both dependent on RBM39 and expresses relatively high levels of DCAF15…

… Inducing proximity among these proteins facilitates the transfer … degron within RBM39 as
well as the residues in DCAF15 that … system for structural and functional studies of RBM39, we …

… experiments reveal that indisulam promotes the interaction between … DCAF15 and the
neosubstrate RNA-binding protein RBM39, which was subsequently ubiquitinated and degraded …

… (a) Chemical structures of indisulam, E7820, CQS, and … of DCAF15, while RBM39 has low
binding affinity with DCAF15. … subsequently promotes cyclin K ubiquitination and degradation. …

… proteasomal degradation of ARNT through CRL4 DCAF15 … examined whether degradation
of both RBM39 and RBM23 … proteins and DCAF15 facilitates ARNT degradation. However…

… (h) Structural view of the E7820-DCAF15-RBM39(RRM2) ternary complex showing the …
evaluated RBM39 degradation using a fluorescent reporter system, in which wt or mutant RBM39 …