Synthesis of Polymerized Melanin by Cryptococcus neoformans in Infected Rodents

AL Rosas, JD Nosanchuk, M Feldmesser… - Infection and …, 2000 - Am Soc Microbiol
polymerized melanin was made during infection, we attempted to isolate fungal melanin
particles from infected rodent … took advantage of the fact that melanin is resistant to the protease, …

[HTML][HTML] Cryptococcus neoformans melanization incorporates multiple catecholamines to produce polytypic melanin

RP Baker, C Chrissian, RE Stark… - Journal of Biological …, 2022 - ASBMB
… of tissue and that melanin pigment synthesized in vivo is … as a polymerization precursor is
capable of producing melanin … display reduced virulence in mice and decreased melanization …

Capsule and melanin synthesis in Cryptococcus neoformans

DC McFadden, A Casadevall - Medical Mycology, 2001 - Taylor & Francis
polymerized melanin is synthesized during infection (see below). Synthesis of polymerized
melanin in … Second, melanin ghosts were isolated from infected mice but not from uninfected …

Cryptococcus neoformans laccase catalyses melanin synthesis from both D-and L-DOPA

HC Eisenman, M Mues, SE Weber, S Frases… - …, 2007 - microbiologyresearch.org
… This would suggest that melanin polymerization occurs with the cell wall acting as a …
Inhibition of melanization with glyphosate improves experimental cryptococcal infection in mice. …

Melanization of Cryptococcus neoformans Affects Lung Inflammatory Responses during Cryptococcal Infection

AJ Mednick, JD Nosanchuk… - Infection and immunity, 2005 - Am Soc Microbiol
… it could conceivably polymerize host substrates into melanin in … that melanin ghosts can be
recovered from mice infected … not only catalyzes the synthesis of melanin but also has direct …

Glyphosate Inhibits Melanization of Cryptococcus neoformans and Prolongs Survival of Mice after Systemic Infection

JD Nosanchuk, R Ovalle… - The Journal of infectious …, 2001 - academic.oup.com
neoformans to synthesize melanin is essential for virulence [6, 7]. Melanins are amorphous,
… with melanin polymerization or rearrangement may be useful therapeutics in the treatment of …

The contribution of melanin to microbial pathogenesis

JD Nosanchuk, A Casadevall - Cellular microbiology, 2003 - Wiley Online Library
… dihydroxyphenylalanine to synthesize melanin. Microbes can … Direct evidence for the
polymerization of melanin in vivo was … Cryptococcus neoformans melanin is involved in the …

Catecholamine Oxidative Products, but Not Melanin, Are Produced by Cryptococcus neoformans during Neuropathogenesis in Mice

L Liu, K Wakamatsu, S Ito, PR Williamson - Infection and immunity, 1999 - Am Soc Microbiol
… Wangiella dermatitidis synthesize melanin from endogenous … In contrast, within rodent brain,
the highest level of … ), a concentration not optimal for melanin polymerization. In addition, as …

Detection of Melanin-Like Pigments in the Dimorphic Fungal Pathogen Paracoccidioides brasiliensis In Vitro and during Infection

BL Gómez, JD Nosanchuk, S Dı́ez… - Infection and …, 2001 - Am Soc Microbiol
… on the melanization of Cryptococcus neoformans. In this … did not produce a band of polymerized
DOPA-melanin. … suggestive evidence for enzymatic synthesis of melanin in yeast cells, …

Melanin: Structure, Function, and Biosynthesis in Cryptococcus

D Trofa, A Casadevall… - Cryptococcus: From …, 2010 - Wiley Online Library
… rearrangement through sequential polymerization, followed by … of infected mice were taken
7 days after infection, and mice … and nonmelanized Cryptococcus neoformans to the melanin-…