Synthesis, affinity at 5-HT2A, 5-HT2B and 5-HT2C serotonin receptors and structure-activity relationships of a series of cyproheptadine analogues
MA Honrubia, J Rodriguez, R Dominguez… - Chemical and …, 1997 - jstage.jst.go.jp
… Cyproheptadine has been chosen by our group as the starting point of a search for … of the
cyproheptadine analogues 2f—j and 3b at the 5-HT2A, 5-HT23 and 5HTZC receptors correlate …
cyproheptadine analogues 2f—j and 3b at the 5-HT2A, 5-HT23 and 5HTZC receptors correlate …
Application of ligand SAR, receptor modeling and receptor mutagenesis to the discovery and development of a new class of 5-HT2A ligands
RB Westkaemper, RA Glennon - Current Topics in Medicinal …, 2002 - ingentaconnect.com
… with 5-HT2A, 5HT2B, and 5-HT2C subpopulations [1]. Depending on the … of parallel
structure-activity relationships between two series of … Several cyproheptadine analogs with altered …
structure-activity relationships between two series of … Several cyproheptadine analogs with altered …
Theoretical study of the interaction of agonists with the 5-HT2A receptor
ME Silva - 2009 - epub.uni-regensburg.de
… The discrimination of 5-HT2A, 5-HT2C and 5-HT2C receptors … studies focused on analogs
of the 5-HT2A receptor antagonist … quantitative structure-activity relationships (QSAR) and to …
of the 5-HT2A receptor antagonist … quantitative structure-activity relationships (QSAR) and to …
PHARMACOPHORIC EVALUATION OF 5-HT2A AND 5-HT2B SEROTONIN RECPEPTORS
P Hemanth - 2021 - scholarscompass.vcu.edu
… at 5-HT2B receptors, a series of DOX analogues was analyzed … structure-activity relationships
of risperidone antagonism at … 5-HT1D, 5-HT2A, 5-HT2C, and sigma-1 receptors.Fen clearly …
of risperidone antagonism at … 5-HT1D, 5-HT2A, 5-HT2C, and sigma-1 receptors.Fen clearly …
[图书][B] Approaches to the study of serotonin 5-HT (2) receptors: Reciprocal mutation, spect imaging, and a new class of phenylalkylamines
CS Dowd - 1999 - search.proquest.com
… This receptor family is comprised of three subtypes: 5HT2A, 5-HT2B, and 5-HT2C receptors.
-… Among these, mutagenesis, imaging, and structure-activity relationship (SAR) formulation …
-… Among these, mutagenesis, imaging, and structure-activity relationship (SAR) formulation …
Life beyond kinases: structure-based discovery of sorafenib as nanomolar antagonist of 5-HT receptors
X Lin, XP Huang, G Chen, R Whaley… - Journal of medicinal …, 2012 - ACS Publications
… , we choose ketanserin and cyproheptadine to represent the … (67-70) Structure–activity
relationship (SAR) studies on … study, we designed series of sorafenib analogues to assess the …
relationship (SAR) studies on … study, we designed series of sorafenib analogues to assess the …
Pharmacophore models for metabotropic 5-HT receptor ligands
AJ Bojarski - Current topics in medicinal chemistry, 2006 - ingentaconnect.com
… points, each group of tricyclic 2-aminotetralin analogues was … previously discussed [40]
structure-activity relationships: (a) … , namely 5-HT2A, 5-HT2B and 5-HT2C receptors. Like the 5-…
structure-activity relationships: (a) … , namely 5-HT2A, 5-HT2B and 5-HT2C receptors. Like the 5-…
Serotonin7 receptors (5-HT7Rs) and their ligands
M Leopoldo - Current medicinal chemistry, 2004 - ingentaconnect.com
… Structureactivity relationships (SAR) of these ligands will … 5-HT receptor subtypes, except
5-HT2A (30-fold), 5-HT2B (50-… were also selective over 5-HT2C and 5-HT6 receptors, and to a …
5-HT2A (30-fold), 5-HT2B (50-… were also selective over 5-HT2C and 5-HT6 receptors, and to a …
Evidence for Possible Involvement of 5-HT2B Receptors in the Cardiac Valvulopathy Associated With Fenfluramine and Other Serotonergic Medications
RB Rothman, MH Baumann, JE Savage, L Rauser… - Circulation, 2000 - Am Heart Assoc
… high affinities for a particular serotonin receptor subtype … In addition to having activity at
a wide range of 5-HT receptors… 2 –family receptors and fenfluramine analogues; right arrow …
a wide range of 5-HT receptors… 2 –family receptors and fenfluramine analogues; right arrow …
Locomotor and peripheral effects of sibutramine modulated by 5-HT2 receptors
SS Frassetto, A Della Santa Rubio… - Canadian journal of …, 2006 - cdnsciencepub.com
… re-uptake, but without affinity to histamine and muscarinic receptors. On the other hand, … HT
2 receptors, since these effects were completely antagonized by cyproheptadine in the group …
2 receptors, since these effects were completely antagonized by cyproheptadine in the group …