Synthesis, molecular docking and kinetic properties of β-hydroxy-β-phenylpropionyl-hydroxamic acids as Helicobacter pylori urease inhibitors

…, JJ Dong, RC Deng, XD Wang, H Ouyang… - European journal of …, 2013 - Elsevier
… was putatively proposed to understand the inconsistency between the crystallographic
and kinetic studies for the first time, which is supported by our molecular docking studies. …

Discovery of Novel Dihydropyrimidine and hydroxamic acid hybrids as potent Helicobacter pylori Urease inhibitors

R Mamidala, SRS Bhimathati, A Vema - Bioorganic Chemistry, 2021 - Elsevier
Kinetic studies revealed that a mixed inhibition with both … , we synthesized two series of
DHPM based hydroxamic acids … by molecular docking studies wherein the hydroxamic acid

… AND MOLECULAR DOCKING STUDIES OF HYDROXAMIC ACID DERIVATIVES AS NOVEL CLASS INHIBITORS AGAINST HELICOBACTER PYLORI UREASE

IT Ibrahim, A Uzairu, B Sagagi - The Journal of Engineering and …, 2019 - periodicos.ufv.br
… R.; Holzle, DL.; Velaparthi, S.; Bai, H.; Brunsteiner, M.; Blond, SY; Petukhov, PJ Synthesis,
molecular docking and kinetic properties of β-hydroxy-β-phenylpropionyl-hydroxamic acids as …

Synergizing structure and function: Cinnamoyl hydroxamic acids as potent urease inhibitors

LPS Viana, GM Naves, IG Medeiros, AS Guimarães… - Bioorganic …, 2024 - Elsevier
… Among ureolytic pathogenic bacteria, Helicobacter pylori is of … , we synthesized and evaluated
the ureolytic properties of a … acids 4a, 4e, 4i, and 4k on the kinetics of type III urease from …

[PDF][PDF] MOLECULAR DOCKING STUDIES OF HYDROXAMIC ACID DERIVATIVES AS NOVEL CLASS INHIBITORS AGAINST HELICOBACTER PYLORI UREASE

IT IBRAHIM, A UZAIRU, B SAGAGI - 2016 - academia.edu
… R.; Holzle, DL.; Velaparthi, S.; Bai, H.; Brunsteiner, M.; Blond, SY; Petukhov, PJ Synthesis,
molecular docking and kinetic properties of β-hydroxy-β-phenylpropionyl-hydroxamic acids as …

Insights into the design of inhibitors of the urease enzyme-a major target for the treatment of Helicobacter pylori infections

AT Fiori-Duarte, RP Rodrigues… - Current Medicinal …, 2020 - ingentaconnect.com
… , including natural, synthetic and semisynthetic products … kinetics describe a competitive
inhibition profile for compound 58 and a noncompetitive profile for 60, while molecular docking

An overview on the synthetic urease inhibitors with structure-activity relationship and molecular docking

W Yang, Q Feng, Z Peng, G Wang - European Journal of Medicinal …, 2022 - Elsevier
kinetics, structure-activity relationship, and molecular docking. The … by Helicobacter pylori
infection through inhibiting urease … of β-hydroxy-β-phenylpropionyl hydroxamic acid 20 were …

Identification of novel urease inhibitors: pharmacophore modeling, virtual screening and molecular docking studies

R Arora, U Issar, R Kakkar - Journal of Biomolecular Structure and …, 2018 - Taylor & Francis
molecules as Helicobacter pylori urease inhibitors. A suitable three-featured pharmacophore
model comprising one H-bond acceptor and two H-bond donor features … involving synthesis

Computational Strategies Targeting Inhibition of Helicobacter pylori and Cryptococcus neoformans Ureases

M Fabris, NM Nascimento-Júnior… - Current …, 2023 - ingentaconnect.com
… Enzyme kinetic studies revealed that this compound … Based on the above considerations,
molecular docking is a … from novel oxoindoline derivatives: Synthesis, biological evaluation and …

In vitro Anti-Helicobacter pylori, Anti-urease and Anti-gastric Cancer Activities of Novel Hydrazones

Z Maryam, B Kaya, HE Bostancı, D Kısa, İ Çelik… - Journal of Molecular …, 2024 - Elsevier
… In this study, new hydrazone derivatives were synthesized by … Molecular docking assessments
on the most potent derivatives were also performed to determine the mode of inhibition. …