… T-cell memory, its biological characteristics and protective capacity can be imprinted at the
time of immune … and maintenance of T-cell memory, its function, and ability to control disease. …

… most effective T cells in a protective immune response against any given infectious agent may
come from a particular functionally defined subset of T cells … + T cells for improved memory …

… For acute self-limiting infections a vaccine is successful if it elicits memory at least as good …
effective T-cell memory formation and augment protective immunity induced by vaccines (see …

… memory CD4 T cells are the prime mediators of vaccine-induced … more until now, confirm
these findings and are considered good evidence for memory CD4 T-cell-mediated immune …

… to that of experimental models demonstrating quicker and better—“memory… memory. But it
also has practical consequences on how we should maintain protective immunity with vaccines…

… to provide a good correlate for protection against a number … -6/CAF01 vaccine maintained
high levels of protective immune … -α + IL-2 + multifunctional T cells with Ag-specific proliferative …

… memory’, as defined in textbooks (ie earlier and better … for vaccine responses and why
have we not been successful in developing preventive or therapeutically protective vaccines’, …

… of vaccines. Understanding the signals that drive the generation of protective memory CD4
T-cells and … by which they act will facilitate the design and development of improved vaccines. …

… In proposing a set of working principles to enable protective memory T cells by vaccination
… , occurs at the time of priming by favoring the induction of memory T cells best fit for …

… and better responses often correlate with protective immunity, … of protective antibody or
activity of highly activated effector T … efficient vaccines that maintain activated T cell responses (…