… to cardiac alternans. Therefore, we hypothesized … restoring deficient SERCA2a by
gene transfer will significantly reduce arrhythmogenic cardiac alternans in the failing heart…

… heart failure gene therapy: i) new insights on calcium regulation by SERCA2a; ii) SERCA2a
as a gene therapy target … is a major predictor of electrical instability and arrhythmias. Hence, …

… vivo with provocation protocols aimed at producing reentry … of sarcoplasmic reticulum
calcium ATPase 2a (SERCA2a) … by luminal Ca 2+ may also have been altered to a more stable …

… Restoration of sarcoplasmic reticulum Ca 2+ uptake through activation of sarcoplasmic/endoplasmic
reticulum calcium ATPase 2a … FKBP12.6 also contributes to stabilization of the RyR2 …

… lumen of the sarcoplasmic reticulum during muscle relaxation… in failing cardiomyocytes and
have used targeted gene delivery. A … Ca 2+ /calmodulin-dependent protein kinase II, which …

… , reduced calcium loading in cardiac sarcoplasmic reticulum (SR), and … muscle type (2a)
splicing variant of SERCA2 gene is the … RyR stabilization may improve SR calcium load and the …

… of heart failure, and gene transfer therapies aimed at restoring … In failing human hearts,
PLN levels remain stable, whereas … positive outcomes in NYHA class II-III HF patients with …

… A first-in-human, phase 1 trial was conducted to restore the … , and implantable cardiac
defibrillators and were on stable (at least … heart failure on the basis of a novel strategy of targeting …

… SERCA2a as a therapeutic target. Pharmacological agents that … A stable energetic state in
rat hearts was confirmed from 31 P … in failing compared with sham LVs, as shown in Figure 2A. …

… Restoration of contractile function in isolated cardiomyocytes from failing human hearts by
gene transfer of … Stable myocardial-specific AAV6-S100A1 gene therapy results in chronic …